In this study, the aim was to investigate the effect of an evidence-based practice course on the lifelong learning skills and problem-solving skills of health science students. A prospective one-group pre-test--post-test design. The universe of the study consisted of 189 students from Cankiri Karatekin University. Student information form, Jefferson lifelong learning skill scale, Problem-solving inventory (PSI) were used as data collection instruments. The sample of the study consisted of 156 students who completed the 14-week course and fully completed the pre-test and post-test. For data analysis, IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp. package program was used. While 84% of the students said that they had never heard of the term EBP before, 91.7% of those who knew the term said they had heard it in their field courses. The lifelong learning skill scale total score change of the students, the PSI total score change of the students after the 26-h EBP course were statistically significant. EBP is very important for health science students to increase their problem-solving success and lifelong learning skills, and it should be integrated into the curriculum.