During COVID-19 lockdowns, online learning activities had to be developed for the Undergraduate and Masters by Coursework Bioinformatics students at RMIT University. Therefore, we designed an integrative, industry-based research assignment, which guided the students through a drug discovery project from target identification to lead optimization. The students were able to utilize this real-life scenario to apply multiple diverse but complementary bioinformatic principles to analyze biological and chemical data leading to meaningful predictions. This activity was utilized as a final assessment of the students' knowledge.