This paper demonstrates the design as a hypothesis framework for developing cross-university students and mentors, and rural youth (aged 18-30) and regional business ecosystems capacity building practice approaches to support sustainable development goals. To support university students', mentors and the business partners' engagement and building agency and capacity with regional rural young women a gamified learning and co-working WINnovators Space (https://winnovators-space.eu/) with e-learning materials for self-learning and entrepreneurial mentored group challenges was developed. The Pilot study validates the capacity building practice approach with WINnovator Space in three countries involving young rural women, higher education students, academic and business mentors -- Estonia (30), Slovenia (35), Serbia (25). [For the full proceedings, see ED636095.]