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ERIC Number: EJ1347800
Record Type: Journal
Publication Date: 2022-Jun
Pages: 4
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1072-0502
EISSN: EISSN-1549-5485
D1/5 Dopamine Receptors Are Necessary for Learning a Novel Context
Sayegh, Fares; Herraiz, Laurie; Colom, Morgane; Lopez, Sébastien; Rampon, Claire; Dahan, Lionel
Learning & Memory, v29 n6 p142-145 Jun 2022
Dopamine participates in encoding memories and could either encode rewarding/aversive value of unconditioned stimuli or act as a novelty signal triggering contextual learning. Here we show that intraperitoneal injection of the dopamine D1/5R antagonist SCH23390 impairs contextual fear conditioning and tone-shock association, while intrahippocampal injection only impairs contextual fear conditioning. By using the context pre-exposure facilitation effect test, we show that SCH23390 is able to block the encoding of the context during the pre-exposure phase. Thus, we provide additional evidence that dopamine is involved in encoding conjunctive representations of new contexts.
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Publication Type: Journal Articles; Reports - Descriptive
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A