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Bisby, Madelyne A.; Baker, Kathryn D.; Richardson, Rick – Learning & Memory, 2018
NMDA receptors (NMDARs) are considered critical for the consolidation of extinction but recent work challenges this assumption. Namely, NMDARs are not required for extinction retention in infant rats as well as when extinction training occurs for a second time (i.e., reextinction) in adult rats. In this study, a possible third instance of…
Descriptors: Fear, Learning Processes, Conditioning, Brain
Baker, Kathryn D.; McNally, Gavan P.; Richardson, Rick – Learning & Memory, 2013
Adolescent rats exhibit impaired extinction retention compared to pre-adolescent and adult rats. A single nonreinforced exposure to the conditioned stimulus (CS; a retrieval trial) given shortly before extinction has been shown in some circumstances to reduce the recovery of fear after extinction in adult animals. This study investigated whether a…
Descriptors: Memory, Fear, Animals, Adolescents
Baker, Kathryn D.; McNally, Gavan P.; Richardson, Rick – Learning & Memory, 2012
The NMDA receptor partial agonist d-cycloserine (DCS) enhances the extinction of learned fear in rats and exposure therapy in humans with anxiety disorders. Despite these benefits, little is known about the mechanisms by which DCS promotes the loss of fear. The present study examined whether DCS augments extinction retention (1) through reductions…
Descriptors: Anxiety Disorders, Context Effect, Anxiety, Fear