This study examined the links between COVID-19 psychosocial stressors, ethnic discrimination, COVID-19 fears, and their combined effects on mental health outcomes among U.S.-based Latinx college students (N = 148; M[subscript age] = 20.68, SD = 2.53). Findings showed that sleep and eating disturbances, emotional distress, and work disruptions were linked with fear of contamination, fear of social distancing, and fear of pandemic impact. Further, ethnic discrimination was found to uniquely contribute to COVID-19 fears above and beyond COVID-19 psychosocial stressors. Finally, COVID-19 emotional distress and COVID fear of pandemic impact were significantly linked to anxiety and depression symptomatology. Recommendations for practice and future research are provided.