Background: To demonstrate the feasibility of outpatient endometrial sampling to evaluate abnormal uterine bleeding in a population of women with intellectual disability. Method: Retrospective chart review was completed of all endometrial biopsies performed on women attending a dedicated gynaecology clinic for women with intellectual disability over an 8-year period. A fine calibre disposable suction curette was utilized. Results: Of the 64 women sampled, adequate tissue for pathological diagnosis was obtained in 84%. Of the 35 with post-menopausal bleeding, a pathological diagnosis was reported in 86% including one endometrial adenocarcinoma. Intravenous sedation was necessary in 12 cases. Conclusions: Endometrial sampling can be successfully performed on an outpatient basis in women with intellectual disability. Most were performed without sedation in a clinic setting suggesting that this technique is generally applicable in this population.