Reading comprehension is among the most challenging and complex skills to teach and research. Doing both well is critical to improving the reading comprehension proficiency of 67% of grade 4 students in U.S. public schools who scored below basic on the 2022 National Assessment of Educational Progress. This Chapter presents Knowledge Acquisition and Transformation (KAT) as a model of an evidence-based technology reading comprehension intervention. With a decade-long history of intervention design, development, and evaluation, KAT has caused positive, meaningful, and statistically significant effects on upper elementary students' reading comprehension. KAT developers accomplished this by integrating theory, practice, technology, and evidence while progressing through iterative cycles of intervention development and evaluation.