Technological advances such as Learning Management System (LMS) are changing the teaching-learning conditions, organization of school activities and functions of educators. In particular, the use of LMS in the educational field is necessary due to the appearance of the SARS-CoV-2 virus. This quantitative research analyzes the teachers' perception about the use of LMS during the COVID-19 pandemic considering data science. The sample is 115 teachers from the National Autonomous University of Mexico. These teachers took the "Classroom of the Future 2020" Diploma in order to create new educational spaces. The results of the machine learning technique indicate that the performance of the school activities in LMS positively influences the learning process, motivation and participation of the students during the COVID-19 pandemic. Also, the decision tree technique identifies three predictive models about the use of this technological tool in the educational field considering the academic level and sex of the teachers. In conclusion, educators can improve the learning conditions, organize creative activities inside and outside the classroom, achieve the innovation in the educational context and build virtual spaces through LMS.