In this article, the authors describe how Team-Based Learning (TBL) intentionally promotes learning strategies that learning sciences research has identified as highly effective to create powerful learning environments for students. The article illustrates how learning sciences principles and research findings inform and support the TBL framework, focusing on six evidence-based learning science strategies: (1) effortful retrieval practice; (2) spaced/distributed retrieval practice; (3) self-elaboration; (4) use of activities employing concrete examples; (5) appropriate sequencing of direct instruction and student exploration; and, (6) repeated use of highly-structured group-based activities throughout a course. The systematic and intentional integration of these strategies in TBL classes creates the potential for powerful learning relative to courses that fail to intentionally take into account learning sciences research in their design and pedagogy.