In recent years, university research in Cambodia has seen new developments and potential transformations although many challenges remain. Drawing on data from in-depth interviews with 22 Cambodian academics, this study shows that the development of university research in Cambodia is constrained by various challenges and barriers to research, preventing Cambodia from promoting higher education internationalization and transforming itself into a knowledge-based society. The study highlights key challenges that limit possibilities for further positive developments of higher education research and suggests the need for policy reforms to make a difference to the university research landscape in Cambodia. The study also points to the broader issues of North-South knowledge divide and calls for national and institutional initiatives to support Cambodian academics and empower them to enhance their research engagement. Finally, the study discusses implications for future research.