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Direct linkLiu, Shifeng; Bourgeois, Florence T.; Dunn, Adam G. – Research Synthesis Methods, 2022
A substantial proportion of trial registrations are not linked to corresponding published articles, limiting analyses and new tools. Our aim was to develop a method for finding articles reporting the results of trials that are registered on ClinicalTrials.gov when they do not include metadata links. We used a set of 27,280 trial registration and…
Descriptors: Medical Research, Web Sites, Identification, Computational Linguistics
Download full textSpybrook, Jessaca; Maynard, Rebecca; Anderson, Dustin – Grantee Submission, 2022
The practice of prospectively registering the details of intervention studies in a public database or registry is gaining momentum across disciplines as a strategy for increasing the transparency, credibility, and accessibility of study findings. In this article, we consider five registries that may be relevant for registration of intervention…
Descriptors: Prevention, Intervention, Databases, Credibility
Günhan, Burak Kürsad; Röver, Christian; Friede, Tim – Research Synthesis Methods, 2020
Meta-analyses of clinical trials targeting rare events face particular challenges when the data lack adequate numbers of events for all treatment arms. Especially when the number of studies is low, standard random-effects meta-analysis methods can lead to serious distortions because of such data sparsity. To overcome this, we suggest the use of…
Descriptors: Meta Analysis, Medical Research, Drug Therapy, Bayesian Statistics
