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Double-Blind Maintenance Safety and Effectiveness Findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) Study
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Findling, Robert L.; Johnson, Jacqueline L.; McClellan, Jon; Frazier, Jean A.; Vitiello, Benedetto; Hamer, Robert M.; Lieberman, Jeffrey A.; Ritz, Louise; McNamara, Nora K.; Lingler, Jacqui; Hlastala, Stefanie; Pierson, Leslie; Puglia, Madeline; Maloney, Ann E.; Kaufman, Emily Michael; Noyes, Nancy; Sikich, Linmarie – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To examine the long-term safety and efficacy of three antipsychotics in early-onset schizophrenia spectrum disorders. Method: Patients (8 to 19 years old) who had improved during an 8-week, randomized, double-blind acute trial of olanzapine, risperidone, or molindone (plus benztropine) were eligible to continue on the same medication…
Descriptors: Maintenance, Safety, Schizophrenia, Drug Therapy
Olanzapine versus Placebo in Adolescents with Schizophrenia; a 6-Week, Randomized Double-Blind, Placebo-Controlled Trial
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Kryzhanovskaya, Ludmila; Schulz, Charles; McDougle, Christopher; Frazier, Jean; Dittman, Ralf; Robertson-Plouch, Carol; Bauer, Theresa; Xu, Wen; Wang, Wei; Carlson, Janice; Tohen, Mauricio – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
The efficacy of olanzapine in treating schizophrenia was tested through a placebo-controlled trial involving one hundred seven inpatient and outpatients adolescents. Patients who took olanzapine experienced significant symptom improvement.
Descriptors: Patients, Adolescents, Schizophrenia, Drug Therapy
Substance Use and the Treatment of Resistant Depression in Adolescents
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Goldstein, Benjamin I.; Shamseddeen, Wael; Spirito, Anthony; Emslie, Graham; Clarke, Greg; Wagner, Karen Dineen; Asarnow, Joan Rosenbaum; Vitiello, Benedetto; Ryan, Neal; Birmaher, Boris; Mayes, Taryn; Onorato, Matthew; Zelazny, Jamie; Brent, David A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Objective: Despite the known association between substance use disorders and major depressive disorder (MDD) among adolescents, little is known regarding substance use among adolescents with MDD. Method: Youths with MDD who had not improved after an adequate selective serotonin reuptake inhibitor trial (N = 334) were enrolled in the Treatment of…
Descriptors: Sexual Abuse, Schizophrenia, Drug Use, Suicide
Atypical and Typical Antipsychotics in the Schools
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Noggle, Chad A.; Dean, Raymond S. – Psychology in the Schools, 2009
The use of antipsychotic medications within the school-age population is rapidly increasing. Although typical antipsychotics may be used in rare cases, this influx is largely secondary to the availability of the atypical antipsychotics. Reduction of possible adverse effects and increased efficacy represent the primary basis for the atypical…
Descriptors: Pervasive Developmental Disorders, Eating Disorders, Attention Deficit Hyperactivity Disorder, Behavior Disorders
Deficits in Interval Timing Measured by the Dual-Task Paradigm among Children and Adolescents with Attention-Deficit/Hyperactivity Disorder
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Hwang, Shoou-Lian; Gau, Susan Shur-Fen; Hsu, Wen-Yau; Wu, Yu-Yu – Journal of Child Psychology and Psychiatry, 2010
Background: The underlying mechanism of time perception deficit in long time intervals in attention-deficit/hyperactivity disorder (ADHD) is still unclear. This study used the time reproduction dual task to explore the role of the attentional resource in time perception deficits among children and adolescents with ADHD. Methods: Participants…
Descriptors: Intelligence, Intervals, Schizophrenia, Attention Deficit Hyperactivity Disorder
Is There a Role for Clozapine in the Treatment of Children and Adolescents?
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Findling, Robert L.; Frazier, Jean A.; Gerbino-Rosen, Ginny; Kranzler, Harvey N.; Kumra, Sanjiv; Kratochvil, Christopher J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
This article presents responses to the question of whether clozapine is ever appropriate to use in the pediatric population. Among others, Jean A. Frazier also agreed that clozapine is appropriate for use in the pediatric population. Clozapine has truly revolutionized the treatment of refractory patients with schizophrenia at any age. This agent…
Descriptors: Patients, Adolescents, Schizophrenia, Pediatrics
Clozapine Treatment of Childhood-Onset Schizophrenia: Evaluation of Effectiveness, Adverse Effects, and Long-Term Outcome
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Sporn, Alexandra L.; Vermani, Anoop; Greenstein, Deanna K.; Bobb, Aaron J.; Spencer, Edgar P.; Clasen, Liv S.; Tossell, Julia W.; Stayer, Catherine C.; Gochman, Peter A.; Lenane, Marge C.; Rapoport, Judith L.; Gogtay, Nitin – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: Clozapine is a unique atypical antipsychotic with superior efficacy in treatment-resistant schizophrenia. Plasma concentration of clozapine and its major metabolite N-desmethylclozapine (NDMC) as well as the ratio of NDMC to clozapine have been reported to be predictors of clozapine response. Here we evaluate these as well as other…
Descriptors: Schizophrenia, Rating Scales, Correlation, Drug Therapy
Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS): Rationale, Design, and Methods
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McClellan, Jon; Sikich, Linmarie; Findling, Robert L.; Frazier, Jean A.; Vitiello, Benedetto; Hlastala, Stefanie A.; Williams, Emily; Ambler, Denisse; Hunt-Harrison, Tyehimba; Maloney, Ann E.; Ritz, Louise; Anderson, Robert; Hamer, Robert M.; Lieberman, Jeffrey A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: The Treatment of Early Onset Schizophrenia Spectrum Disorders Study is a publicly funded clinical trial designed to compare the therapeutic benefits, safety, and tolerability of risperidone, olanzapine, and molindone in youths with early-onset schizophrenia spectrum disorders. The rationale, design, and methods of the Treatment of Early…
Descriptors: Safety, Schizophrenia, Autism, Quality of Life
Hormonal Correlates of Clozapine-Induced Weight Gain in Psychotic Children: An Exploratory Study
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Sporn, Alexandra L.; Bobb, Aaron J.; Gogtay, Nitin; Stevens, Hanna; Greenstein, Deanna K.; Clasen, Liv S.; Tossell, Julia W.; Nugent, Thomas; Gochman, Peter A.; Sharp, Wendy S.; Mattai, Anand; Lenane, Marge C.; Yanovski, Jack A.; Rapoport, Judith L. – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: Weight gain is a serious side effect of atypical antipsychotics, especially in childhood. In this study, the authors examined six weight gain-related hormones in patients with childhood-onset schizophrenia (COS) after 6 weeks of clozapine treatment. Method: Fasting serum samples for 24 patients with COS and 21 matched healthy controls…
Descriptors: Psychiatry, Patients, Schizophrenia, Obesity
Hematological Adverse Events in Clozapine-Treated Children and Adolescents
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Gerbino-Rosen, Ginny; Roofeh, David; Tompkins, D. Andrew; Feryo, Doug; Nusser, Laurie; Kranzler, Harvey; Napolitano, Barbara; Frederickson, Anne; Henderson, Inika; Rhinewine, Joe; Kumra, Sanjiv – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: To retrospectively examine rates of hematological adverse events (HAEs) in psychiatrically ill, hospitalized children treated with clozapine. Method: Clozapine treatment was administered in an open-label fashion using a flexible titration schedule, and data from weekly complete blood counts was obtained. The rate of neutropenia and…
Descriptors: Psychiatry, Hospitalized Children, Drug Therapy, Adolescents
Borderline and Psychotic Adolescents: Borderline Symptomatology from Childhood--Actual Therapeutic Approach
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Aarkrog, Tove – Journal of Youth and Adolescence, 1977
The symptoms of, and possible treatments for 21 borderline and psychotic adolescents who had suffered from borderline psychoses in childhood were examined from a developmental point of view. It was concluded that therapeutic possibilities exist. Some childhood symptoms could be used directly in treatment, while others disappeared with general…
Descriptors: Adolescents, Drug Therapy, Emotional Disturbances, Handicapped Children
A Comparative Study of Clinical Correlates in Schizophrenia with Onset in Childhood, Adolescence and Adulthood
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Biswas, Parthasarathy; Malhotra, Savita; Malhotra, Anil; Gupta, Nitin – Journal of Indian Association for Child and Adolescent Mental Health, 2006
Background: Childhood onset schizophrenia (COS) is a rare disorder. Comparative data on the effect of differential age of onset on clinical profile in schizophrenia are very few. Method: Subjects with COS (n = 15), adolescence onset schizophrenia (AdOS, n = 20) and adulthood onset schizophrenia (AOS, n = 20) were compared on socio-demographic,…
Descriptors: Schizophrenia, Intelligence Quotient, Psychopathology, Children