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Measurement Properties of the German Version of the Cambridge Examination for Mental Disorders of Older People with Down Syndrome and Others with Intellectual Disabilities (CAMDEX-DS)
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Sandra V. Loosli; Lennart C. Neumann; Elisabeth Wlasich; Catharina Prix; Laura Koll; Endy Weidinger; Jonathan Vöglein; Olivia Wagemann; Adrian Danek; Georg Nübling; Johannes Levin – Journal of Intellectual & Developmental Disability, 2024
Background: The CAMDEX-DS is an instrument to diagnose Alzheimer's disease (AD) in Down syndrome consisting of an informant interview and a cognitive test battery (CAMCOG-DS). Measurement properties of the German CAMDEX-DS were investigated. Method: Fifty-five adults with Down syndrome (19-58 years) participated in this observational study.…
Descriptors: Foreign Countries, Diagnostic Tests, Alzheimers Disease, Down Syndrome
Is Heart Disease a Risk Factor for Low Dementia Test Battery Scores in Older Persons with Down Syndrome? Exploratory, Pilot Study, and Commentary
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Percy, Maire E.; Lukiw, Walter J. – International Journal of Developmental Disabilities, 2020
Objectives: Certain heart conditions and diseases are common in Down syndrome (DS; trisomy 21), but their role in early onset dementia that is prevalent in older adults with DS has not been evaluated. To address this knowledge gap, we conducted a study of risk factors for low neurocognitive/behavioral scores obtained with a published dementia test…
Descriptors: Heart Disorders, Risk, Dementia, Scores
A Neuroimaging Proof of Principle Study of Down's Syndrome and Dementia: Ethical and Methodological Challenges in Intrusive Research
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d'Abrera, J. C.; Holland, A. J.; Landt, J.; Stocks-Gee, G.; Zaman, S. H. – Journal of Intellectual Disability Research, 2013
Background: Research into specific illnesses and the development of new treatments may only become possible as new technologies become available. When used for research, such technologies may best be described as "intrusive", in that they require a considerable willingness and commitment on the part of the participants. This has…
Descriptors: Down Syndrome, Dementia, Ethics, Neurological Impairments
Alzheimer's Disease in Down Syndrome: Neurobiology and Risk
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Zigman, Warren B.; Lott, Ira T. – Mental Retardation and Developmental Disabilities Research Reviews, 2007
Down syndrome (DS) is characterized by increased mortality rates, both during early and later stages of life, and age-specific mortality risk remains higher in adults with DS compared with the overall population of people with mental retardation and with typically developing populations. Causes of increased mortality rates early in life are…
Descriptors: Heart Disorders, Alzheimers Disease, Mortality Rate, Down Syndrome
The Assessment of Behavioural Decline in Adults with Down's Syndrome.
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McKenzie, Karen; Harte, Cyan; Patrick, Shona; Matheson, Edith; Murray, George C. – Journal of Learning Disabilities (United Kingdom), 2002
A study examined two methods of using the Vineland Adaptive Behavior Scales with people with Down syndrome at risk of developing Alzheimer's disease. Scoring the scales using the basal rule outlined in the manual resulted in highlighting significant declines in scores for those meeting the criteria for "probable Alzheimer's disease."…
Descriptors: Adults, Alzheimers Disease, At Risk Persons, Behavior Change