Publication Date
| In 2025 | 0 |
| Since 2024 | 0 |
| Since 2021 (last 5 years) | 0 |
| Since 2016 (last 10 years) | 1 |
| Since 2006 (last 20 years) | 7 |
Descriptor
| Alzheimers Disease | 7 |
| Brain | 7 |
| Down Syndrome | 7 |
| Adults | 5 |
| Neurological Impairments | 4 |
| Aging (Individuals) | 3 |
| At Risk Persons | 3 |
| Dementia | 3 |
| Mental Retardation | 3 |
| Age Differences | 2 |
| Clinical Diagnosis | 2 |
| More ▼ | |
Source
| Journal of Intellectual… | 3 |
| American Journal on… | 1 |
| Brain and Cognition | 1 |
| Mental Retardation and… | 1 |
| Research in Autism Spectrum… | 1 |
Author
| Berney, T. P. | 1 |
| Devenny, D. A. | 1 |
| Handen, Benjamin L. | 1 |
| Holland, A. J. | 1 |
| Kay, D. W. K. | 1 |
| Kittler, P. | 1 |
| Krinsky-McHale, S. J. | 1 |
| Landt, J. | 1 |
| Lott, Ira T. | 1 |
| Margallo-Lana, M. L. | 1 |
| Moore, P. B. | 1 |
| More ▼ | |
Publication Type
| Journal Articles | 7 |
| Reports - Research | 4 |
| Reports - Descriptive | 2 |
| Reports - Evaluative | 1 |
Education Level
| Adult Basic Education | 1 |
Audience
Location
| United Kingdom (Cambridge) | 1 |
Laws, Policies, & Programs
Assessments and Surveys
| Adaptive Behavior Scale | 1 |
What Works Clearinghouse Rating
Peer reviewed
Direct linkHanden, Benjamin L. – American Journal on Intellectual and Developmental Disabilities, 2020
Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid…
Descriptors: Adults, Down Syndrome, Alzheimers Disease, At Risk Persons
d'Abrera, J. C.; Holland, A. J.; Landt, J.; Stocks-Gee, G.; Zaman, S. H. – Journal of Intellectual Disability Research, 2013
Background: Research into specific illnesses and the development of new treatments may only become possible as new technologies become available. When used for research, such technologies may best be described as "intrusive", in that they require a considerable willingness and commitment on the part of the participants. This has…
Descriptors: Down Syndrome, Dementia, Ethics, Neurological Impairments
Prandota, Joseph – Research in Autism Spectrum Disorders, 2011
"Toxoplasma gondii" is a protozoan parasite that infects about a third of human population. It is generally believed that in immunocompetent hosts, the parasite infection takes usually asymptomatic course and induces self-limiting disease, but in immunocompromised individuals may cause significant morbidity and mortality. "T. gondii" uses sulfated…
Descriptors: Metabolism, Autism, Alzheimers Disease, Diseases
Nelson, Linda D.; Scheibel, Kevin E.; Ringman, John M.; Sayre, James W. – Brain and Cognition, 2007
Measures developed from animal models of aging may detect dementia of the Alzheimer's type in a population at-risk for Alzheimer's disease (AD). Although, by middle age, individuals with Down syndrome (DS) show an extraordinarily high prevalence of AD-type pathology, their severe idiopathic cognitive deficits tend to confound the "clinical"…
Descriptors: Pathology, Animals, Alzheimers Disease, Down Syndrome
Zigman, Warren B.; Lott, Ira T. – Mental Retardation and Developmental Disabilities Research Reviews, 2007
Down syndrome (DS) is characterized by increased mortality rates, both during early and later stages of life, and age-specific mortality risk remains higher in adults with DS compared with the overall population of people with mental retardation and with typically developing populations. Causes of increased mortality rates early in life are…
Descriptors: Heart Disorders, Alzheimers Disease, Mortality Rate, Down Syndrome
Kittler, P.; Krinsky-McHale, S. J.; Devenny, D. A. – Journal of Intellectual Disability Research, 2006
Background: Verbal intrusion errors are irrelevant responses made in the course of verbal memory retrieval or language production that have been associated with disruption of executive functions and the prefrontal cortex. They have been observed to occur more frequently both with normal aging and with neurodegenerative diseases such as Alzheimer's…
Descriptors: Down Syndrome, Semantics, Intervals, Word Lists
Margallo-Lana, M. L.; Moore, P. B.; Kay, D. W. K.; Perry, R. H.; Reid, B. E.; Berney, T. P.; Tyrer, S. P. – Journal of Intellectual Disability Research, 2007
Background: The clinical and neuropathological features associated with dementia in Down's syndrome (DS) are not well established. Aims: To examine clinico-pathological correlations and the incidence of cognitive decline in a cohort of adults with DS. Method: A total of 92 hospitalized persons with DS were followed up from 1985 to December 2000.…
Descriptors: Adjustment (to Environment), Adults, Patients, Incidence
