Using a hippocampus-dependent contextual threat learning and memory task, we report widespread, coordinated DNA methylation changes in CA1 hippocampus of Sprague-Dawley rats specific to threat learning at genes involved in synaptic transmission. Experience-dependent alternations in gene expression and DNA methylation were observed as early as 1 h…

Background: In the UK, general practitioners/family physicians receive pay for performance on management of long-term conditions, according to best-practice indicators. Method: Management of long-term conditions was compared between 721 adults with intellectual disabilities and the general population (n = 764,672). Prevalence of long-term…

Aragón, Acevedo-Díaz and García-Carmona study prospective biology teachers' understanding of the Nature of Science (NOS). In my comment, I would first like to step back and ask "what it is to understand something", i.e. the sciences. I will turn to a quasi-Wittgensteinian epistemological tradition and suggest that, contrary to our habit…

Palliative care services have not been developed in Northern Cyprus despite the increased incidence of cancer cases in recent years. The aim of this study is to measure the level of knowledge of the people living in country on palliative care services by conducting an awareness research. People who reside in Northern Cyprus have been surveyed via…

This study examines the epistemic disciplinary knowledge that students consider when addressing a real food emergency that requires their engagement in inquiry and argumentation practices. The study comprised two phases: (1) designing an experiment to study the emergency and (2) evaluating the real outcome of the emergency. The participants were…

We designed and evaluated a student laboratory workshop on plant-based vaccines against the SARS-CoV-2 virus. The workshop focused on hands-on laboratory techniques, including DNA extraction from rice seeds, where the recombinant protein was produced, detection of the transgene, and basic concepts on how vaccines work in the human body to offer…

Meta-analysis of 2 × 2 tables is common and useful in research topics including analysis of adverse events and survey research data. Fixed-effects inference typically centers on measures of association such as the Cochran-Mantel-Haenszel statistic or Woolf's estimator, but relies on assuming exact homogeneity across studies, which is often…

Early childhood educator preparation program curricula contain limited course work and accompanying field experiences on chronic illness management and supporting young children with these conditions. The current study examines data from 319 kindergarten to third grade teachers from the southeastern United States and their perceptions of statewide…

The drift diffusion model (DDM) is a widely applied computational model of decision making that allows differentiation between latent cognitive and residual processes. One main assumption of the DDM that has undergone little empirical testing is the level of independence between cognitive and motor responses. If true, widespread incorporation of…

It is of great importance that science educators teach COVID-19 and related pandemics to boost students' scientific literacy. A mixed methods research design (pre-post test instrument [N = 86] and semi-structured interviews [N = 11]--August 2020 to June 2021) evaluated the ability of an intervention (12 h, three-session, 3-day, online workshop) to…

In a country where English is not a native language, the language course designs for undergraduate medical students may usually underscore the instruction of language itself (e.g., grammar). This study demonstrated how literature (i.e., stories in this study) and the practice of art were integrated into the pedagogy of English for Medical…

Purpose: Virtual reality (VR) technologies have expanded their application domains towards education with pedagogical benefits including fully immersive learning environment and in-depth user engagement through scenario-based virtual simulations. Motion sickness (MS), however, has become one of the long-standing key challenges of the VR…

Metabolic Syndrome (MetS), a cluster of cardiometabolic abnormalities including elevated waist circumference, low high-density lipoprotein (HDL) cholesterol, high triglycerides, high blood pressure, and elevated fasting glucose, affects nearly 35% of American adults. The presence of MetS both predicts and contributes to the development of…

This article describes a collaborative writing project involving narratives of health and caregiving. An interdisciplinary seminar titled "Narratives of Illness and Care" examines literary and medical narratives to better understand disease, therapeutic communication, empathy, and the social determinants of health. During the COVID-19…

Spatial working memory (SWM) is the ability to encode, maintain, and retrieve spatial information over a temporal gap, and relies on a network of structures including the medial septum (MS), which provides critical input to the hippocampus. Although the role of the MS in SWM is well-established, up until recently, we have been unable to use…