Meta-analyses in orphan diseases and small populations generally face particular problems, including small numbers of studies, small study sizes and heterogeneity of results. However, the heterogeneity is difficult to estimate if only very few studies are included. Motivated by a systematic review in immunosuppression following liver…

Background: Many reviews aim to compare numerous treatments and report results stratified by subgroups (eg, by disease severity). In such cases, a network meta-analysis model including treatment by covariate interactions can estimate the relative effects of all treatment pairings for each subgroup of patients. Two key assumptions underlie such…

Duchenne muscular dystrophy is a progressive muscle-wasting condition that only affects boys, most use a wheelchair by the age of 12 and increasing levels of support and medical intervention are needed as they mature into young adulthood. Medical research is working to find treatments and an eventual cure for Duchenne muscular dystrophy, and this…

Discusses the symptoms, treatment, and help for sufferers of Tourette's syndrome. (BF/JH)

Cognitive and behavioral effects of temporarily elevating levels of phenylalanine in treated phenylketonuria (PKU) were investigated in a triple-blind crossover study with 16 early and continuously treated children and adolescents with PKU. Results suggest that intellectual ability, memory, and conduct are not affected by medium-term elevated…

Progress has been made in the separation of the various components of whole blood, methods of storage, and efficient use of blood components, permitting better management of blood quality in children undergoing chemotherapy and radiotherapy in the treatment of cancer. (MB)

Epidemiologic research has revealed a wide spectrum of etiologic information concerning childhood cancer. (MB)

This report describes the activities of the Edna McConnell Clark Foundation for the 1993 fiscal year. Organized in 1950, the foundation's grant activities focus on five areas: children, disadvantaged youth, homeless families, justice, and tropical disease research. The report provides: (1) a brief history of the foundation and its activities; (2)…

PREPARED BY THE NATIONAL ADVISORY COMMITTEE ON EDUCATION OF THE DEAF, THE BOOKLET EXPLAINS PROGRAMS SPONSORED BY THE DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE FOR THE PURPOSE OF ASSISTING DEAF CHILDREN AND YOUTH TO DEVELOP THEIR TALENTS AND PREPARE FOR RESPONSIBLE CITIZENSHIP. SEVERAL SCHOOLS ARE DISCUSSED, SOME ESTABLISHED (GALLAUDET COLLEGE)…