This manual is intended to assist pesticide applicators who are engaged in right-of-way pest control to meet the requirements of the Michigan Department of Agriculture for certification. While the majority of material in this guide pertains to vegetation management, the guide also addresses right-of-way insect and fungus control. An introduction with the explanation of right-of-way areas is presented. The seven sections included describe: (1) Right-of-way vegetation management; (2) Insect and fungus control; (3) Managing aquatic plants; (4) Sources of injury to non-target organisms; (5) Environmental considerations; (6) Sources of information and recommendations; and (7) Applicator responsibilities. Section one discusses types of plants, action of herbicides, types of herbicides, herbicide application techniques, application equipment, factors affecting chemical weed control, factors affecting foliage application, factors affecting soil applied herbicides, and weather factors affecting chemical weed control. A list of self-help questions is presented at the end of some sections. (HM)