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Direct linkRogers, Jack T.; Cahill, Catherine M. – Learning & Memory, 2020
A set of common-acting iron-responsive 5'untranslated region (5'UTR) motifs can fold into RNA stem loops that appear significant to the biology of cognitive declines of Parkinson's disease dementia (PDD), Lewy body dementia (LDD), and Alzheimer's disease (AD). Neurodegenerative diseases exhibit perturbations of iron homeostasis in defined brain…
Descriptors: Neurological Impairments, Dementia, Brain, Cognitive Processes
Handen, Benjamin L. – American Journal on Intellectual and Developmental Disabilities, 2020
Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid…
Descriptors: Adults, Down Syndrome, Alzheimers Disease, At Risk Persons
Ossewaarde, Roelant; Jonkers, Roel; Jalvingh, Fedor; Bastiaanse, Roelien – Journal of Speech, Language, and Hearing Research, 2020
Purpose: Corpus analyses of spontaneous language fragments of varying length provide useful insights in the language change caused by brain damage, such as caused by some forms of dementia. Sample size is an important experimental parameter to consider when designing spontaneous language analyses studies. Sample length influences the confidence…
Descriptors: Speech Communication, Dementia, Computational Linguistics, Neurological Impairments
Dunford, Christine Mary; Yoshizaki-Gibbons, Hailee M.; Morhardt, Darby – Research in Drama Education, 2017
There is a recognised need for research that illuminates mutually beneficial connections among performance, ageing, disability theory, and praxis. One such project is the Memory Ensemble™, an improvisational theatre intervention for persons with early stage Alzheimer's disease and related dementias (ADRD). This case study explores how the…
Descriptors: Dementia, Aging (Individuals), Memory, Cognitive Ability
Halpin-Healy, Carolyn – Journal of Museum Education, 2017
Arts & Minds programs aim to promote well-being for people with dementia and their care partners. Educators must balance the needs of participants with the given conditions of display in the museum. While connection to the art historical canon is a consideration for program planning, the choice of artworks for contemplation and dialogue…
Descriptors: Dementia, Well Being, Alzheimers Disease, Art History
d'Abrera, J. C.; Holland, A. J.; Landt, J.; Stocks-Gee, G.; Zaman, S. H. – Journal of Intellectual Disability Research, 2013
Background: Research into specific illnesses and the development of new treatments may only become possible as new technologies become available. When used for research, such technologies may best be described as "intrusive", in that they require a considerable willingness and commitment on the part of the participants. This has…
Descriptors: Down Syndrome, Dementia, Ethics, Neurological Impairments
Ruparelia, Aarti; Pearn, Matthew L.; Mobley, William C. – Developmental Disabilities Research Reviews, 2013
Down syndrome (DS) is one of many causes of intellectual disability (ID), others including but not limited to, fetal alcohol syndrome, Fragile X syndrome, Rett syndrome, Williams syndrome, hypoxia, and infection. Down syndrome is characterized by a number of neurobiological problems resulting in learning and memory deficits and early onset…
Descriptors: Aging (Individuals), Older Adults, Mental Retardation, Down Syndrome
McKee, Ann C.; Stein, Thor D.; Nowinski, Christopher J.; Stern, Robert A.; Daneshvar, Daniel H.; Alvarez, Victor E.; Lee, Hyo-Soon; Hall, Garth; Wojtowicz, Sydney M.; Baugh, Christine M.; Riley, David O.; Kubilus, Caroline A.; Cormier, Kerry A.; Jacobs, Matthew A.; Martin, Brett R.; Abraham, Carmela R.; Ikezu, Tsuneya; Reichard, Robert Ross; Wolozin, Benjamin L.; Budson, Andrew E.; Goldstein, Lee E.; Kowall, Neil W.; Cantu, Robert C. – Brain, 2013
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging…
Descriptors: Neurological Impairments, Head Injuries, Chronic Illness, Brain
Gollan, Tamar H.; Salmon, David P.; Montoya, Rosa I.; Galasko, Douglas R. – Neuropsychologia, 2011
The current study investigated the relationship between bilingual language proficiency and onset of probable Alzheimer's disease (AD) in 44 Spanish-English bilinguals at the UCSD Alzheimer's Disease Research Center. Degree of bilingualism along a continuum was measured using Boston Naming Test (BNT) scores in each language. Higher degrees of…
Descriptors: Alzheimers Disease, Language Proficiency, Bilingualism, Predictor Variables
Anderson, Lynda A.; Day, Kristine L.; Beard, Renee L.; Reed, Peter S.; Wu, Bei – Gerontologist, 2009
The present review assesses the public's perceptions about cognitive health and Alzheimer's disease among adults in the United States. We searched the published literature and Internet, and contacted experts in the field to locate surveys assessing the public's perceptions about cognition. We found 10 eligible surveys and abstracted data…
Descriptors: Alzheimers Disease, Brain, Mental Health, Memory
Chow, Maggie L.; Brambati, Simona M.; Gorno-Tempini, Maria Luisa; Miller, Bruce L.; Johnson, Julene K. – Brain and Cognition, 2010
Modern cognitive neuroscientific theories and empirical evidence suggest that brain structures involved in movement may be related to action-related semantic knowledge. To test this hypothesis, we examined the naming of environmental sounds in patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), two…
Descriptors: Semantics, Alzheimers Disease, Diseases, Cerebral Palsy
Krinsky-McHale, Sharon J.; Devenny, Darlynne A.; Kittler, Phyllis; Silverman, Wayne – American Journal on Mental Retardation, 2008
Adults with Down syndrome and early stage Alzheimer's disease showed decline in their ability to selectively attend to stimuli in a multitrial cancellation task. They also showed variability in their performance over the test trials, whereas healthy participants showed stability. These changes in performance were observed approximately 2 years…
Descriptors: Alzheimers Disease, Dementia, Attention Span, Down Syndrome
Garbutt, Siobhan; Matlin, Alisa; Hellmuth, Joanna; Schenk, Ana K.; Johnson, Julene K.; Rosen, Howard; Dean, David; Kramer, Joel; Neuhaus, John; Miller, Bruce L.; Lisberger, Stephen G.; Boxer, Adam L. – Brain, 2008
Frontotemporal lobar degeneration (FTLD) often overlaps clinically with corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP), both of which have prominent eye movement abnormalities. To investigate the ability of oculomotor performance to differentiate between FTLD, Alzheimer's disease, CBS and PSP, saccades and smooth pursuit were…
Descriptors: Neurological Impairments, Alzheimers Disease, Eye Movements, Dementia
Fernandez-Duque, Diego; Black, Sandra E. – Brain and Cognition, 2008
This study explored possible deficits in selective attention brought about by Dementia of Alzheimer Type (DAT). In three experiments, we tested patients with early DAT, healthy elderly, and young adults under low memory demands to assess perceptual filtering, conflict resolution, and set switching abilities. We found no evidence of impaired…
Descriptors: Dementia, Attention, Young Adults, Patients
Whitlatch, Carol – Journal of Social Work Education, 2008
It is estimated that 13 million to 15 million adults in the United States have chronic conditions that impair cognitive function, such as Alzheimer's disease, stroke, Parkinson's disease, and traumatic brain injury. The growing number of people with chronic conditions that include cognitive impairment and the family members who assist them face…
Descriptors: Identification, Intervention, Chronic Illness, Interpersonal Relationship
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