The problem is teacher attrition among students with emotional and behavioral disorders (EBDs) in the southeastern United States. Addressing this problem is vital to improving outcomes for students with EBDs. The purpose of this basic qualitative study was to explore factors related to teacher retention and quality instruction when working with students with EBDs in the southeastern United States. Gaps in literature existed regarding teachers' attitudes and instructional knowledge associated with students with EBDs. Conservation of resources theory and self-determination theory provided the theoretical framework for the study. Research questions guided the study in exploring teachers' opinions on factors affecting teacher retention among those teaching students with EBDs and the perception of teachers regarding instructional practices that best meet the needs of these students. Using a basic qualitative design, this study included 15 public school teachers within the southeastern United States with at least one year of experience working with a student with EBDs. Data instruments include an open-ended questionnaire and a semi-structured interview, both conducted through online platforms. Data analysis involved organizing and coding data to determine emerging themes to answer research questions. Results indicated teacher knowledge, support, and student deficits as contributing factors to teacher retention among students with EBDs. Teachers also identified engaging instruction, effective instructional delivery, supportive classroom practices, and behavioral support as essential components of instruction for students with EBDs. Improving preservice teacher programs and providing adequate training are essential to improving outcomes for students with EBDs. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]