In this article, I systematically review evidence on the relations between oral reading fluency (ORF) and reading comprehension (RC) for adolescents with limited reading proficiency (ALRP) in Grades 6 to12. I organized findings from 23 studies into five themes: (a) unclear role of ORF in the simple view of reading model for ALRP, (b) ALRP have distinct reader profiles, (c) ORF consists of more than automaticity, (d) the role of ORF varies, and (e) oral reading automaticity has tenuous predictive value for ALRP. Results suggest that knowledge of an adolescent's ORF, as commonly defined and assessed, provides helpful information about an adolescent's reader profile but is not sufficient to evaluate instructional needs or measure progress. I conclude the article with a discussion on implications for researchers, assessment developers, practitioners, and school administrators.