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Pakhomov, Serguei V. S.; Hemmy, Laura S.; Lim, Kelvin O. – Neuropsychologia, 2012
The objective of our study is to introduce a fully automated, computational linguistic technique to quantify semantic relations between words generated on a standard semantic verbal fluency test and to determine its cognitive and clinical correlates. Cognitive differences between patients with Alzheimer's disease and mild cognitive impairment are…
Descriptors: Semantics, Alzheimers Disease, Diseases, Patients
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Vemuri, Prashanthi; Weigand, Stephen D.; Przybelski, Scott A.; Knopman, David S.; Smith, Glenn E.; Trojanowski, John Q.; Shaw, Leslie M.; Decarli, Charlie S.; Carmichael, Owen; Bernstein, Matt A.; Aisen, Paul S.; Weiner, Michael; Petersen, Ronald C.; Jack, Clifford R., Jr. – Brain, 2011
The objective of this study was to investigate how a measure of educational and occupational attainment, a component of cognitive reserve, modifies the relationship between biomarkers of pathology and cognition in Alzheimer's disease. The biomarkers evaluated quantified neurodegeneration via atrophy on magnetic resonance images, neuronal injury…
Descriptors: Alzheimers Disease, Reading Tests, Verbal Learning, Pathology
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Peisah, Carmelle; Snowdon, John; Kril, Jillian; Rodriguez, Michael – Suicide and Life-Threatening Behavior, 2007
The neuropathological correlates of suicide in older persons have received little research attention. Our recent study of elderly suicide victims from an Australian forensic medicine department (n = 143), unlike a previous case-control study, did not find an increased prevalence of Alzheimer's disease (AD) in older persons who committed suicide…
Descriptors: Alzheimers Disease, Dementia, Suicide, Pathology
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Hellweg, Rainer; Huber, Roman; Kuhl, Alexander; Riepe, Matthias W.; Lohmann, Peter – Learning & Memory, 2006
Impairment of hippocampal function precedes frontal and parietal cortex impairment in human Alzheimer's disease(AD). Neurotrophins are critical for behavioral performance and neuronal survival in AD. We used complex and radial mazes to assess spatial orientation and learning in wild-type and B6-Tg(ThylAPP)23Sdz (APP23) animals, a transgenic mouse…
Descriptors: Neurological Impairments, Nonverbal Learning, Correlation, Memory
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Margallo-Lana, M. L.; Moore, P. B.; Kay, D. W. K.; Perry, R. H.; Reid, B. E.; Berney, T. P.; Tyrer, S. P. – Journal of Intellectual Disability Research, 2007
Background: The clinical and neuropathological features associated with dementia in Down's syndrome (DS) are not well established. Aims: To examine clinico-pathological correlations and the incidence of cognitive decline in a cohort of adults with DS. Method: A total of 92 hospitalized persons with DS were followed up from 1985 to December 2000.…
Descriptors: Adjustment (to Environment), Adults, Patients, Incidence
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Papagno, Costanza; Allegra, Adele; Cardaci, Maurizio – Brain and Cognition, 2004
The aim of this study was to evaluate the role of short-term memory and attention in time estimation. For this purpose we studied prospective time verbal estimation in 21 patients with Alzheimer's disease (AD), and compared their performance with that of 21 matched normal controls in two different conditions: during a digit span task and during an…
Descriptors: Group Dynamics, Correlation, Neurological Impairments, Comparative Analysis
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Burton, Catherine; Crossley, Margaret – Canadian Journal on Aging, 2003
The Saskatchewan Mood Inventory (SMI) is a caregiver-focused assessment and research tool that was designed to enhance understanding of the emotional experiences of individuals with dementia and to identify relationships between level of cognitive impairment and family member ratings of pleasant and unpleasant emotional responses during daily…
Descriptors: Emotional Response, Dementia, Foreign Countries, Psychological Patterns
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Sano, Mary; Aisen, Paul S.; Dalton, Arthur J.; Andrews, Howard F.; Tsai, Wei-Yann – Journal of Policy and Practice in Intellectual Disabilities, 2005
A major challenge to developing therapeutic interventions for cognitive loss and dementia in aging individuals with Down syndrome (DS) is the selection of appropriate outcome measures. This report describes the adaptation of the Brief Praxis Test (a nonverbal cognitive test) as a primary outcome measure, as well as the selection of secondary…
Descriptors: Mental Retardation, Alzheimers Disease, Dementia, Down Syndrome