The integration of science, technology, engineering, and mathematics (STEM)-based digital learning has shown a significant impact on enhancing the 6C skills (character, citizenship, critical thinking, creative thinking, collaboration, and communication) of elementary school students. This quasi-experimental study, involving 200 participants from primary schools, compared the efficacy of STEM-based digital learning against STEM-conventional methods in fostering these essential twenty-first-century skills. Data were collected through case study tests and analyzed to evaluate the differences in skill development between the two groups. The results indicate a noticeable improvement in the 6C skills among students engaged in STEM-based digital learning compared to those in STEM-conventional settings, with the former group achieving higher average scores across the skill set. These findings highlight the value of adopting STEM-based digital learning in elementary education to better prepare students with the competencies necessary for their future. This research underscores the positive influence of innovative learning models on developing critical life skills in elementary school students.