This study aims to analyze the influence of Self-Leadership, Self-Efficacy on students' entrepreneurship creativity using digital-based applications in managing online businesses. This study uses a quantitative approach and the type of comparative causal research. The population of this research is all students of Makassar State University who are online business entrepreneurs are 210 people. Determination of the number of samples using the Slovin formula so that a sample of 152 people was obtained. Sampling is based on probability sampling technique, namely Simple Random Sampling. Data collection techniques are questionnaires and analyzed using descriptive statistical analysis and multiple linear regression. The results showed that self-leadership and self-efficacy had an effect on student entrepreneurship creativity, either partially or simultaneously. The implication of the research results is to increase the entrepreneurial creativity of students, it is necessary to pay attention to the factors of Self-Leadership and Self-Efficacy.