Purpose: The role of a structured program of exercise training on the low-risk pregnancy in Iranian women undergoing "in vitro" fertilization (IVF) based on the reduction of gestational diabetes was examined. Method: A comparative quasi-experimental clinical trial with 170 IVF-pregnant women in two intervention and control groups was studied to monitor the training effect of physical activities in terms of walking, and aerobic, strength-conditioning, and relaxation exercises during pregnancy on the improvement of maternal and fetal health. Gestational diabetes as the main complication was evaluated with 2-h 75-g OGTT and FBS tests in 24-28 and 34- weeks' gestation, respectively. Other adverse maternal (e.g., preeclampsia, cesarean section, and preterm delivery) and neonatal (e.g., intrauterine growth retardation, low/high birth weight, and fetal death) outcomes were determined and analyzed by statistical and regression tests. Results: A significantly lower gestational diabetes and preeclampsia rate was found in the intervened IVF-pregnant women with the maintenance of an active lifestyle. Although there was no significant difference in other negative maternal and neonatal outcomes between the two groups, lower symptoms from these complications were recorded in IVF-pregnant women trained with regular exercise activities. Conclusion: Implementing the physical activity program by IVF-women during pregnancy is an effective intervention strategy in reducing the risk of adverse maternal and fetal outcomes.