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Methods to Calculate Uncertainty in the Estimated Overall Effect Size from a Random-Effects Meta-Analysis
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Veroniki, Areti Angeliki; Jackson, Dan; Bender, Ralf; Kuss, Oliver; Langan, Dean; Higgins, Julian P. T.; Knapp, Guido; Salanti, Georgia – Research Synthesis Methods, 2019
Meta-analyses are an important tool within systematic reviews to estimate the overall effect size and its confidence interval for an outcome of interest. If heterogeneity between the results of the relevant studies is anticipated, then a random-effects model is often preferred for analysis. In this model, a prediction interval for the true effect…
Descriptors: Meta Analysis, Effect Size, Simulation, Comparative Analysis
Methods to Estimate the Between-Study Variance and Its Uncertainty in Meta-Analysis
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Veroniki, Areti Angeliki; Jackson, Dan; Viechtbauer, Wolfgang; Bender, Ralf; Bowden, Jack; Knapp, Guido; Kuss, Oliver; Higgins, Julian P. T.; Langan, Dean; Salanti, Georgia – Research Synthesis Methods, 2016
Meta-analyses are typically used to estimate the overall/mean of an outcome of interest. However, inference about between-study variability, which is typically modelled using a between-study variance parameter, is usually an additional aim. The DerSimonian and Laird method, currently widely used by default to estimate the between-study variance,…
Descriptors: Meta Analysis, Methods, Computation, Simulation