Background information, procedures, and results are provided for an experiment demonstrating techniques of solvent selection, gradient elution, pH control, and ion-pairing in the analysis of an analgesic mixture using reversed-phase liquid chromatography on an octadecylsilane column. Although developed using sophisticated/expensive equipment, less…

Describes an experiment on the qualitative analysis of several over-the-counter analgesic tablets. Background information, procedures used (including high pressure liquid chromatography), and typical student results are included. (JN)

Pharmacology is taught on a dedicated module for nurse prescribers who have a limited physical science background. To facilitate learning a problem-based approach was adopted. However, to enhance students' knowledge of drug action a PharmaCALogy software package from the British Pharmacological Society was used. Students were alternately given a…

Describes the chemical analysis and rating system used at "Consumer Reports" in rating antacids. Discusses considerations made concerning dosage and duration of 12 common brands of antacid. (CW)

Describes the use of a computer-assisted teaching system (CATS) for teaching pharmacology to health professionals. The CATS is composed of two parts: computer-assisted instruction and computer-managed instruction. These parts, program objectives (and the Keller plan to achieve them), instructional units of study, and hardware considerations are…

Describes an experiment to analyze commercial analgesic preparations (pain relievers) by silica gel thin layer chromatography, followed by preparative (thick) layer chromatographic separation and spectroscopic analysis. Key difference from similar experiments is that students are responsible for devising suitable solvent systems for the thin layer…

Describes an interdisciplinary, college-level course on the chemical and physiological properties of selected drugs and medications. The course, which could be adapted for secondary school use, assumes no prior chemical or biological knowledge. Source materials, films used, credit/grading policies, instructional strategies, and course outline are…

One application of modeling is studying the ways in which molecules fit together to form chemical compounds. Describes the forces acting between molecules and how three-dimensional graphical modeling is employed in developing rational principles for drug design. (JN)

Discussed are applications of biochemistry. Included are designed drugs, clever drugs, carcinogenic structures, sugary wine, caged chemicals, biomaterials, marine chemistry, biopolymers, prospecting bacteria, and plant chemistry. (CW)

A computer program that replaces a set of pharmacology and physiology laboratory experiments on live animals or isolated organs is described and illustrated. Five experiments are simulated: dose-effect relationships on smooth muscle, blood pressure and catecholamines, neuromuscular signal transmission, acetylcholine and the circulation, and…

Examines the need for a science of toxicology and training at both the undergraduate and graduate levels in response to legislation controlling drugs, food additives and toxic substances in the work environment, and concern about effects on man. Stresses need for putting toxicology on a scientific base with adequate funding. (JM)

Describes a course provided for health profession-oriented students. Uses a chemical basis to explain the physiology of drug action while considering appropriate patient care. Outlines course content and testing procedures. (Author)

The development and use of computer assisted learning (CAL) materials in the life sciences is well established and, in the UK at least, significant resources have been provided to enable this. Some years on from when the major investments took place teachers are facing the problem that the technologies used to develop and deliver the CAL programs…

This review is divided into these topics: alkaloids, antibiotics, inorganics, nitrogen and oxygen containing compounds, steroids, sulfur containing compounds, vitamins, techniques, and miscellaneous methods. The review covers from November 1986, to October 1988. (MVL)

Discussed is a designer-drug technology called antisense which blocks messenger RNA's ability to carry information to protein producing sites in the cell. The applications of this drug to AIDS research, cancer therapy, and other diseases are discussed. (KR)