A multicomponent reaction was adapted and successfully applied in the major organic course, which involves synthesizing and characterizing a 1,3-benzoxazine derived from paracetamol extracted from tablets of the worldwide well-known medicine Tylenol. Using paracetamol as a reagent is a motivational strategy in undergraduate laboratories to meet…

The utilization of virtual compound libraries and virtual screening has become a routine method in drug discovery and has accelerated the research of pharmacy and translational medicine. With the development of computer-aided drug design (CADD), it is essential to incorporate virtual experiments into the education of medicinal chemistry. Herein,…

Discusses forensic science in general and forensic chemistry in particular, including laboratory techniques used by forensic chemists and toxicologists. (SK)

Provides background information on the development and action of the coumarin family of anticoagulants, focusing on an experimental procedure for the synthesis of dicumerol. Includes procedures used and safety considerations. (JM)

Discusses advantages and disadvantages of using computer simulations (including those involving application of mathematical models) in teaching physiology and pharmacology, indicating that the major benefit is in performing experiments that cannot be performed in the laboratory. Also considers a simulation on the interaction of drugs with…

Discusses programs designed to ease shortage of qualified toxicologists including one leading to a bachelor's degree in toxicology at the Philadelphia College of Pharmacy and Science. Also considered are emerging attitudes toward toxicology and educational issues extending beyond the education of students (such as educating the public,…

Describes a program which simulates animal pharmacology experiments involving "all-or-none" responses. Use of the Applesoft BASIC program in the pharmacology teaching laboratory provides students with a rapid and economical way to gain experience in the design and statistical analysis of quantal dose-response experiments. Information on…

Background information, procedures, and results, are provided for an undergraduate experiment in which analgesic tablets are analyzed using liquid chromatography. The experiment, an improved, modified version of the Waters Associates Inc. experiment, is simple to prepare, requiring little glassware and minimal sample manipulation by students. (JN)

Background information, procedures, and results are provided for an experiment demonstrating techniques of solvent selection, gradient elution, pH control, and ion-pairing in the analysis of an analgesic mixture using reversed-phase liquid chromatography on an octadecylsilane column. Although developed using sophisticated/expensive equipment, less…

Describes an experiment on the qualitative analysis of several over-the-counter analgesic tablets. Background information, procedures used (including high pressure liquid chromatography), and typical student results are included. (JN)

Describes the chemical analysis and rating system used at "Consumer Reports" in rating antacids. Discusses considerations made concerning dosage and duration of 12 common brands of antacid. (CW)

Describes the use of a computer-assisted teaching system (CATS) for teaching pharmacology to health professionals. The CATS is composed of two parts: computer-assisted instruction and computer-managed instruction. These parts, program objectives (and the Keller plan to achieve them), instructional units of study, and hardware considerations are…

Describes an experiment to analyze commercial analgesic preparations (pain relievers) by silica gel thin layer chromatography, followed by preparative (thick) layer chromatographic separation and spectroscopic analysis. Key difference from similar experiments is that students are responsible for devising suitable solvent systems for the thin layer…

Pharmacology is taught on a dedicated module for nurse prescribers who have a limited physical science background. To facilitate learning a problem-based approach was adopted. However, to enhance students' knowledge of drug action a PharmaCALogy software package from the British Pharmacological Society was used. Students were alternately given a…

Describes an interdisciplinary, college-level course on the chemical and physiological properties of selected drugs and medications. The course, which could be adapted for secondary school use, assumes no prior chemical or biological knowledge. Source materials, films used, credit/grading policies, instructional strategies, and course outline are…