Ethical decision-making is inherent to the research ethics committee (REC) deliberation process. While ethical codes, regulations, and research standards are indispensable in guiding this process, decision-making is nonetheless susceptible to nonrational factors that can undermined the quality, consistency, and perceived fairness REC decisions. In this paper I identify biases and heuristics (i.e., nonrational factors) that are known to influence the reasoning processes among the general population and various professions alike. I suggest that such factors will inevitably arise within the REC review process. To help mitigate this potential, I propose an interventive questioning process that can be used by RECs to identify and minimize the influence of the nonrational factors most likely to impact REC judgment and decision-making.