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Direct linkGraham, Bronwyn M.; Richardson, Rick – Learning & Memory, 2011
These experiments examined the effects of the NMDA-receptor (NMDAr) antagonist MK801 on reacquisition and re-extinction of a conditioned fear that had been previously extinguished before injection of fibroblast growth factor-2 (FGF2) or vehicle. Recent findings have shown that relearning and re-extinction, unlike initial learning and extinction,…
Descriptors: Fear, Anxiety, Experimental Psychology, Learning
Nonkes, Lourens J. P.; van de Vondervoort, Ilse I. G. M.; de Leeuw, Mark J. C.; Wijlaars, Linda P.; Maes, Joseph H. R.; Homberg, Judith R. – Learning & Memory, 2012
Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT[superscript -/-]) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting…
Descriptors: Inhibition, Brain, Cognitive Processes, Animals
Tolentino, Jerlyn C.; Pirogovsky, Eva; Luu, Trinh; Toner, Chelsea K.; Gilbert, Paul E. – Learning & Memory, 2012
Two experiments tested the effect of temporal interference on order memory for fixed and random sequences in young adults and nondemented older adults. The results demonstrate that temporal order memory for fixed and random sequences is impaired in nondemented older adults, particularly when temporal interference is high. However, temporal order…
Descriptors: Young Adults, Older Adults, Memory, Learning Processes
Bird, Chris M.; Davies, Rachel A.; Ward, Jamie; Burgess, Neil – Learning & Memory, 2011
The influence of pre-experimental autobiographical knowledge on recognition memory was investigated using as memoranda faces that were either personally known or unknown to the participant. Under a dual process theory, such knowledge boosted both recollection- and familiarity-based recognition judgements. Under an unequal variance signal detection…
Descriptors: Familiarity, Recognition (Psychology), Autobiographies, Investigations
Calandreau, Ludovic; Desgranges, Bertrand; Jaffard, Robert; Desmedt, Aline – Learning & Memory, 2010
The aim of the present experiment was to directly assess the role of the glutamatergic hippocampal-lateral septal (HPC-LS) neurotransmission in tone and contextual fear conditioning. We found that pretraining infusion of glutamatergic acid into the lateral septum promotes tone conditioning and concomitantly disrupts contextual conditioning.…
Descriptors: Context Effect, Conditioning, Fear, Experiments
Theberge, Florence R. M.; Milton, Amy L.; Belin, David; Lee, Jonathan L. C.; Everitt, Barry J. – Learning & Memory, 2010
A distributed limbic-corticostriatal circuitry is implicated in cue-induced drug craving and relapse. Exposure to drug-paired cues not only precipitates relapse, but also triggers the reactivation and reconsolidation of the cue-drug memory. However, the limbic cortical-striatal circuitry underlying drug memory reconsolidation is unclear. The aim…
Descriptors: Cues, Cocaine, Symptoms (Individual Disorders), Classical Conditioning
Baxter, Mark G.; Browning, Philip G. F.; Mitchell, Anna S. – Learning & Memory, 2008
Surgical disconnection of the frontal cortex and inferotemporal cortex severely impairs many aspects of visual learning and memory, including learning of new object-in-place scene memory problems, a monkey model of episodic memory. As part of a study of specialization within prefrontal cortex in visual learning and memory, we tested monkeys with…
Descriptors: Visual Learning, Memory, Brain, Animals
