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Direct linkBrice, Alejandro E.; Wallace, Sarah E.; Brice, Roanne G. – Communication Disorders Quarterly, 2014
Alzheimer's dementia (AD) is a progressive, degenerative disease that occurs in the cerebral cortex due to increased levels of glutamate, the proliferation of plaque-forming amyloid beta proteins, and reactive gliosis. Establishing behavioral indicators of the disease (e.g., impairments of episodic memory) and use of neuroimaging technology…
Descriptors: Alzheimers Disease, Aging (Individuals), Older Adults, Brain
Chang, Yu-Ling; Bondi, Mark W.; Fennema-Notestine, Christine; McEvoy, Linda K.; Hagler, Donald J., Jr.; Jacobson, Mark W.; Dale, Anders M. – Neuropsychologia, 2010
Understanding the underlying qualitative features of memory deficits in mild cognitive impairment (MCI) can provide critical information for early detection of Alzheimer's disease (AD). This study sought to investigate the utility of both learning and retention measures in (a) the diagnosis of MCI, (b) predicting progression to AD, and (c)…
Descriptors: Control Groups, Alzheimers Disease, Correlation, Verbal Learning
Carpenter, Brian D.; Balsis, Steve; Otilingam, Poorni G.; Hanson, Priya K.; Gatz, Margaret – Gerontologist, 2009
Purpose: This study provides preliminary evidence for the acceptability, reliability, and validity of the new Alzheimer's Disease Knowledge Scale (ADKS), a content and psychometric update to the Alzheimer's Disease Knowledge Test. Design and Methods: Traditional scale development methods were used to generate items and evaluate their psychometric…
Descriptors: Alzheimers Disease, Caregivers, Risk, Patients
Nelson, Linda D.; Scheibel, Kevin E.; Ringman, John M.; Sayre, James W. – Brain and Cognition, 2007
Measures developed from animal models of aging may detect dementia of the Alzheimer's type in a population at-risk for Alzheimer's disease (AD). Although, by middle age, individuals with Down syndrome (DS) show an extraordinarily high prevalence of AD-type pathology, their severe idiopathic cognitive deficits tend to confound the "clinical"…
Descriptors: Pathology, Animals, Alzheimers Disease, Down Syndrome
Ball, S. L.; Holland, A. J.; Huppert, F. A.; Treppner, P.; Watson, P.; Hon, J. – Journal of Intellectual Disability Research, 2004
Dementia because of Alzheimer's disease (AD) commonly affects older adults with Down's syndrome (DS). Methods are needed, with established concurrent and predictive validity, to facilitate the diagnostic assessment of dementia, when it is complicated by pre-existing intellectual disabilities (ID). We report on the reliability and validity of a…
Descriptors: Identification, Predictive Validity, Interrater Reliability, Alzheimers Disease
Prigatano, George P.; Smason, Ivan – BNI Quarterly, 1994
Assessing higher cerebral functions in patients with known or suspected dementia requires sampling numerous abilities quickly and accurately. This paper reports on the performance of 20 patients with probable dementia of the Alzheimer's type (DAT) on the BNI Screen for Higher Cerebral Functions (BNI Screen). These patients' performances were…
Descriptors: Alzheimers Disease, Brain Hemisphere Functions, Clinical Diagnosis, Diagnostic Tests
