ERIC Number: EJ1290320
Record Type: Journal
Publication Date: 2021-Mar
Pages: 5
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: N/A
Drug Synthesis and Analysis of an Acetylcholinesterase Inhibitor: A Comprehensive Medicinal Chemistry Experience for Undergraduates
Yang, Jie; Yuan, Yi; Gu, Jing; Li, Ao; Wei, Zhao; Ouyang, Qin
Journal of Chemical Education, v98 n3 p991-995 Mar 2021
As a cross-cutting and comprehensive subject, medicinal chemistry involves the knowledge of chemical, biological, medical, and pharmaceutical sciences. A comprehensive medicinal chemistry experience for undergraduates is expected to train various experimental skills and enhance their scientific research ability. Herein, a series of laboratory and computational experiments performed by undergraduate students were described, including synthesis, acetylation, and activity testing of an acetylcholinesterase inhibitor, tacrine. The inhibition activities of tacrine and acetylated tacrine were discussed based on the results of computer simulations. Moreover, representative student-generated data, methods of the experiments, and an interpretation of student feedback on the project are presented.
Descriptors: Chemistry, Science Instruction, Undergraduate Students, College Science, Medicine, Science Laboratories, Science Experiments, Scientific Concepts, Concept Formation, Biology, Pharmacy, Scientific Research, Science Process Skills, Research Skills
Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Evaluative
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A