General chemistry courses serve as foundational curriculum within most STEM undergraduate curricula, and hence, it is essential to assess student knowledge and application of learning outcomes for courses such as Introduction to Chemistry and Organic Chemistry. Within the United States, paper-and-pencil examinations are typical for measuring…

As electrochemistry continues to gain broader acceptance and use within the organic chemistry community, it is important that advanced undergraduate students are exposed to fundamental and practical knowledge of electrochemical applications for chemical synthesis. Herein, we describe the development of an undergraduate laboratory experience that…

Research has shown that the use of practical examples in undergraduate education promotes the retention of historically underrepresented students in STEM majors and lowers achievement gaps within courses. Since many students of color and women aspire toward careers in healthcare and the pharmaceutical industry, efforts to incorporate medicinal…

A fast, operationally simple, and reproducible synthetic protocol for anthraquinone dyes (AQDs), suitable for upper-division undergraduate industrial and organic chemistry laboratory courses, has been developed. This experiment is composed of three stages; the first step deals with the synthesis of AQDs, followed by a purification step, and…

The effects of kinetic vs thermodynamic control on "endo"/"exo" stereoisomer ratios can be observed in a simple Diels-Alder reaction between "N"-phenylmaleimide and furan. The use of microwave-promoted synthesis affords the cycloadducts in yields ranging from 65-100%, employing reaction times of 1-10 min at…

The electrolysis of water to produce hydrogen is a critical step in many green chemistry processes. The key to the efficiency of water electrolysis is the synthesis of an appropriate electrocatalyst. Three-dimensional (3D) printing is an increasingly important part of many industrial processes. In this study, we propose an efficient laboratory…

Our goal as educators should be to help our students become well positioned to achieve future success. To develop effective strategies for accomplishing this objective, we must first understand the root causes of success. Thus, to best serve undergraduate students who are taking organic chemistry courses, we must understand the attributes that…

Chemistry educators have a responsibility to teach students about the essential role the field of chemistry has in a sustainable future for the planet. Chemical products, such as pharmaceuticals, plastics, electronics, agrochemicals, and building materials, all benefit society yet unintended consequences resulting from the production and use of…

Practical skills in chemistry are considered an essential outcome of an undergraduate chemistry degree. To achieve this, chemistry curricula are designated a substantial number of hours in teaching laboratories. However, the general method of a summative assessment of these sessions is through a written laboratory report and not through the actual…

Embracing diversity, equity and inclusion (DEI) in the chemistry classroom is crucial for creating an inclusive learning environment that will have a positive effect on student's learning, success, and hence, retention in science, technology, engineering and mathematics (STEM). As such, a number of DEI approaches have recently been identified to…

Chemistry students are passionate about using their learning to contribute toward a sustainable future, yet they feel unprepared to make green and sustainable practical decisions informed by industry-relevant tools. Most green chemistry metrics are mass-based, which do not estimate environmental impact or help address global socioeconomic…

Integrating new synthetic methods and experimental techniques from the latest research reports into undergraduate laboratory experiments is of great significance, as it enables students to learn the cutting-edge technology of organic chemistry and cultivates their experimental skills and innovative thinking. In this study, an experiment on their…

Keto-enol tautomerism is a special example of structural isomerism. In this experiment, 6-chlorofulvene is predominantly yielded during the chlorination reaction of 6'-hydroxyfulvene with POCl[subscript 3] in the presence of DMF. The high regioselectivity of this reaction is dominated by intramolecular hydrogen-bonding and steric hindrance,…

A laboratory experiment introducing the concept of chemical bioconjugation of proteins to undergraduate students in a therapeutically relevant context was developed. Initially, students installed an aldehyde functionality into a protein via the oxidation of the N-terminal threonine residue of the cholera toxin subunit B (CTB) protein, which was…

The ACS Guidelines for bachelor's degrees in chemistry call for the curriculum to include polymer chemistry principles and the synthesis of different classes of macromolecules. Organic chemistry can provide an important introduction to polymer chemistry principles, and photochemically induced radical polymerization is one method for generating…