The case study is a widely used methodology among qualitative researchers irrespective of their philosophical orientation. While positivist and interpretive philosophies are the two most popular research philosophies across diverse research fields, critical realism offers a third alternative. Critical realism is a research philosophy that assumes the existence of an independent reality but also accepts that there may be varied interpretations of it due to a difference in context. Mechanisms are the theoretical building blocks of critical realism and presence, absence, or interaction of certain mechanisms may result in the presence or absence of certain events. However, limited guidelines are available on conducting a critical realist case study. This paper fills this gap by providing some practical guidelines on how a CR-based case study may be planned and executed. Practical guidelines are offered for framing the research question, data collection, writing a narrative, coding, and explanation building while following a critical realist philosophy.