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A Neuroimaging Proof of Principle Study of Down's Syndrome and Dementia: Ethical and Methodological Challenges in Intrusive Research
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d'Abrera, J. C.; Holland, A. J.; Landt, J.; Stocks-Gee, G.; Zaman, S. H. – Journal of Intellectual Disability Research, 2013
Background: Research into specific illnesses and the development of new treatments may only become possible as new technologies become available. When used for research, such technologies may best be described as "intrusive", in that they require a considerable willingness and commitment on the part of the participants. This has…
Descriptors: Down Syndrome, Dementia, Ethics, Neurological Impairments
Mediation between Staff and Elderly Persons with Intellectual Disability with Alzheimer Disease as a Means of Enhancing Their Daily Functioning
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Lifshitz, Hefziba; Klein, Pnina S. – Education and Training in Autism and Developmental Disabilities, 2011
This study presents a new way of mediation between staff and elderly persons with intellectual disability (ID) and Alzheimer type dementia (AD), i.e., the MISC (Mediational Intervention for Sensitizing Caregivers (Klein, 1988, 2003) model. The MISC was adopted for interactions between staff and adults with ID and AD based on observations of…
Descriptors: Mental Retardation, Alzheimers Disease, Caregivers, Older Adults
A Mutation Affecting the Sodium/Proton Exchanger, "SLC9A6," Causes Mental Retardation with Tau Deposition
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Garbern, James Y.; Neumann, Manuela; Trojanowski, John Q.; Lee, Virginia M.-Y.; Feldman, Gerald; Norris, Joy W.; Friez, Michael J.; Schwartz, Charles E.; Stevenson, Roger; Sima, Anders A. F. – Brain, 2010
We have studied a family with severe mental retardation characterized by the virtual absence of speech, autism spectrum disorder, epilepsy, late-onset ataxia, weakness and dystonia. Post-mortem examination of two males revealed widespread neuronal loss, with the most striking finding being neuronal and glial tau deposition in a pattern reminiscent…
Descriptors: Severe Mental Retardation, Mental Retardation, Autism, Alzheimers Disease
Brain Substrates of Learning and Retention in Mild Cognitive Impairment Diagnosis and Progression to Alzheimer's Disease
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Chang, Yu-Ling; Bondi, Mark W.; Fennema-Notestine, Christine; McEvoy, Linda K.; Hagler, Donald J., Jr.; Jacobson, Mark W.; Dale, Anders M. – Neuropsychologia, 2010
Understanding the underlying qualitative features of memory deficits in mild cognitive impairment (MCI) can provide critical information for early detection of Alzheimer's disease (AD). This study sought to investigate the utility of both learning and retention measures in (a) the diagnosis of MCI, (b) predicting progression to AD, and (c)…
Descriptors: Control Groups, Alzheimers Disease, Correlation, Verbal Learning
Verbal Intrusions Precede Memory Decline in Adults with Down Syndrome
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Kittler, P.; Krinsky-McHale, S. J.; Devenny, D. A. – Journal of Intellectual Disability Research, 2006
Background: Verbal intrusion errors are irrelevant responses made in the course of verbal memory retrieval or language production that have been associated with disruption of executive functions and the prefrontal cortex. They have been observed to occur more frequently both with normal aging and with neurodegenerative diseases such as Alzheimer's…
Descriptors: Down Syndrome, Semantics, Intervals, Word Lists
Fifteen-Year Follow-Up of 92 Hospitalized Adults with Down's Syndrome: Incidence of Cognitive Decline, Its Relationship to Age and Neuropathology
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Margallo-Lana, M. L.; Moore, P. B.; Kay, D. W. K.; Perry, R. H.; Reid, B. E.; Berney, T. P.; Tyrer, S. P. – Journal of Intellectual Disability Research, 2007
Background: The clinical and neuropathological features associated with dementia in Down's syndrome (DS) are not well established. Aims: To examine clinico-pathological correlations and the incidence of cognitive decline in a cohort of adults with DS. Method: A total of 92 hospitalized persons with DS were followed up from 1985 to December 2000.…
Descriptors: Adjustment (to Environment), Adults, Patients, Incidence
The Owner's Manual for the Brain: Everyday Applications from Mind-Brain Research. Second Edition.
Howard, Pierce J. – 2000
This book discusses what is known about the brain and memory storage and how people can improve their recall of information. There are 10 parts with 37 chapters. Part 1, "Forming a Foundation: The Context for Using Your Owner's Manual," includes topics like brain basics and brain imaging. Part 2, "Wellness: Getting the Most Out of…
Descriptors: Academically Gifted, Aging (Individuals), Alzheimers Disease, Attention Deficit Disorders