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Direct linkCalhoun, Denise – Journal of Adult and Continuing Education, 2022
This paper demonstrates the effects of education on cognitive functioning which could serve as an alternative preventive method to halt or delay cognitive decline in older adults. The purpose of this proposal is to discuss and illustrate the benefits of improving cognitive ability through continuing education. As such, taking advantage of…
Descriptors: Cognitive Ability, Older Adults, Dementia, Correlation
Rogers, Jack T.; Cahill, Catherine M. – Learning & Memory, 2020
A set of common-acting iron-responsive 5'untranslated region (5'UTR) motifs can fold into RNA stem loops that appear significant to the biology of cognitive declines of Parkinson's disease dementia (PDD), Lewy body dementia (LDD), and Alzheimer's disease (AD). Neurodegenerative diseases exhibit perturbations of iron homeostasis in defined brain…
Descriptors: Neurological Impairments, Dementia, Brain, Cognitive Processes
Rachel C. Branco; Holly V. Goodson; Erin M. Jonasson – Journal of Chemical Education, 2022
Case studies are helpful teaching tools that can bring scientific concepts to life. Here, we present a case study related to protein-ligand interactions, amino acids, protein structure, and protein modification. While protein-ligand interaction is a foundational concept within Biochemistry, there are few available case studies that focus on this…
Descriptors: Biochemistry, Science Instruction, Chemistry, Alzheimers Disease
Handen, Benjamin L. – American Journal on Intellectual and Developmental Disabilities, 2020
Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid…
Descriptors: Adults, Down Syndrome, Alzheimers Disease, At Risk Persons
Ammassari-Teule, Martine – Learning & Memory, 2020
Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adaptations which take place in the brain before mice…
Descriptors: Brain, Cognitive Processes, Neurological Organization, Animals
Heuer, Sarah E.; Neuner, Sarah M.; Hadad, Niran; O'Connell, Kristen M. S.; Williams, Robert W.; Philip, Vivek M.; Gaiteri, Chris; Kaczorowski, Catherine C. – Learning & Memory, 2020
Individual differences in cognitive decline during normal aging and Alzheimer's disease (AD) are common, but the molecular mechanisms underlying these distinct outcomes are not fully understood. We utilized a combination of genetic, molecular, and behavioral data from a mouse population designed to model human variation in cognitive outcomes to…
Descriptors: Cognitive Processes, Resilience (Psychology), Alzheimers Disease, Genetics
Download full textPaddock, Brie; Davenport, Caty – HAPS Educator, 2017
Alzheimer's disease is a progressive neurodegenerative disorder characterized by amyloid plaques, synapse dysfunction, and memory loss. The production and accumulation of A[beta] peptides, a major component of the amyloid plaques, is sensitive to many genetic and environmental factors. Recently, research has focused on the role of oxidative stress…
Descriptors: Alzheimers Disease, Physiology, Anatomy, Neurology
Rodriguez, Gustavo A.; Burns, Mark P.; Weeber, Edwin J.; Rebeck, G. William – Learning & Memory, 2013
The apolipoprotein E4 ("APOE-[epsilon]4") allele is the strongest genetic risk factor for developing late-onset Alzheimer's disease, and may predispose individuals to Alzheimer's-related cognitive decline by affecting normal brain function early in life. To investigate the impact of human APOE alleles on cognitive performance in mice, we trained…
Descriptors: Animals, Spatial Ability, Memory, Biochemistry
Lu, Po H.; Lee, Grace J.; Tishler, Todd A.; Meghpara, Michael; Thompson, Paul M.; Bartzokis, George – Brain and Cognition, 2013
Background: To assess the hypothesis that in a sample of very healthy elderly men selected to minimize risk for Alzheimer's disease (AD) and cerebrovascular disease, myelin breakdown in late-myelinating regions mediates age-related slowing in cognitive processing speed (CPS). Materials and methods: The prefrontal lobe white matter and the genu of…
Descriptors: Cognitive Processes, Older Adults, Alzheimers Disease, Brain
d'Abrera, J. C.; Holland, A. J.; Landt, J.; Stocks-Gee, G.; Zaman, S. H. – Journal of Intellectual Disability Research, 2013
Background: Research into specific illnesses and the development of new treatments may only become possible as new technologies become available. When used for research, such technologies may best be described as "intrusive", in that they require a considerable willingness and commitment on the part of the participants. This has…
Descriptors: Down Syndrome, Dementia, Ethics, Neurological Impairments
Brice, Alejandro E.; Wallace, Sarah E.; Brice, Roanne G. – Communication Disorders Quarterly, 2014
Alzheimer's dementia (AD) is a progressive, degenerative disease that occurs in the cerebral cortex due to increased levels of glutamate, the proliferation of plaque-forming amyloid beta proteins, and reactive gliosis. Establishing behavioral indicators of the disease (e.g., impairments of episodic memory) and use of neuroimaging technology…
Descriptors: Alzheimers Disease, Aging (Individuals), Older Adults, Brain
Costa, Albert; Calabria, Marco; Marne, Paula; Hernandez, Mireia; Juncadella, Montserrat; Gascon-Bayarri, Jordi; Lleo, Alberto; Ortiz-Gil, Jordi; Ugas, Lidia; Blesa, Rafael; Rene, Ramon – Neuropsychologia, 2012
In this article we aimed to assess how Alzheimer's disease (AD), which is neurodegenerative, affects the linguistic performance of early, high-proficient bilinguals in their two languages. To this end, we compared the Picture Naming and Word Translation performances of two groups of AD patients varying in disease progression (Mild and Moderate)…
Descriptors: Evidence, Semantics, Linguistics, Alzheimers Disease
Sannino, Sara; Russo, Fabio; Torromino, Giulia; Pendolino, Valentina; Calabresi, Paolo; De Leonibus, Elvira – Learning & Memory, 2012
The dorsal hippocampus is crucial for mammalian spatial memory, but its exact role in item memory is still hotly debated. Recent evidence in humans suggested that the hippocampus might be selectively involved in item short-term memory to deal with an increasing memory load. In this study, we sought to test this hypothesis. To this aim we developed…
Descriptors: Evidence, Animals, Schizophrenia, Alzheimers Disease
Ries, Michele L.; McLaren, Donald G.; Bendlin, Barbara B.; Xu, Guofan; Rowley, Howard A.; Birn, Rasmus; Kastman, Erik K.; Sager, Mark A.; Asthana, Sanjay; Johnson, Sterling C. – Neuropsychologia, 2012
It is tentatively estimated that 25% of people with early Alzheimer's disease (AD) show impaired awareness of disease-related changes in their own cognition. Research examining both normative self-awareness and altered awareness resulting from brain disease or injury points to the central role of the medial prefrontal cortex (MPFC) in generating…
Descriptors: Interaction Process Analysis, Alzheimers Disease, Diseases, Rating Scales
McKee, Ann C.; Stein, Thor D.; Nowinski, Christopher J.; Stern, Robert A.; Daneshvar, Daniel H.; Alvarez, Victor E.; Lee, Hyo-Soon; Hall, Garth; Wojtowicz, Sydney M.; Baugh, Christine M.; Riley, David O.; Kubilus, Caroline A.; Cormier, Kerry A.; Jacobs, Matthew A.; Martin, Brett R.; Abraham, Carmela R.; Ikezu, Tsuneya; Reichard, Robert Ross; Wolozin, Benjamin L.; Budson, Andrew E.; Goldstein, Lee E.; Kowall, Neil W.; Cantu, Robert C. – Brain, 2013
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging…
Descriptors: Neurological Impairments, Head Injuries, Chronic Illness, Brain
