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Lin, Hui-Ching; Mao, Sheng-Chun; Gean, Po-Wu – Learning & Memory, 2006
The cannabinoid CB1 receptor has been shown to be critically involved in the extinction of fear memory. Systemic injection of a CB1 receptor antagonist prior to extinction training blocked extinction. Conversely, administration of the cannabinoid uptake inhibitor AM404 facilitated extinction in a dose-dependent manner. Here we show that bilateral…
Descriptors: Neurological Impairments, Behavioral Science Research, Animals, Fear