Over the last three quarters of a century, international guidelines and regulations have undergone significant changes in how children are problematised as participants in biomedical research. While early guidelines enacted children as vulnerable subjects with diminished autonomy and in need of special protection, beginning in the early 2000s,…

Pathway-based differential expression analysis allows the incorporation of biological domain knowledge into transcriptomics analysis to enhance our understanding of disease mechanisms. To integrate information among multiple studies at the pathway level, pathway-based meta-analysis can be performed. Paired or partially paired samples are common in…

Launching biomedical innovations based on clinical demands instead of translating basic research findings to practice reduces the risk that the results will not fit the clinical routine. To realize this type of innovation, a meta-analysis of the body of research is necessary to reveal demand-matching concepts. However, both the data deluge and the…

Objective: Media are a main source of medical information for the public, as well as for decision makers. This scenario demands a good selection of stories and correct medical reporting. Design: Our study aimed to analyze if journalistic guidelines or similar documents were already available and whether they provided satisfactory advice for…

The House Interstate and Foreign Commerce Committee's regulatory legislation on recombinant DNA technology is discussed along with university reactions to it. Violations of federal guidelines and legal efforts are described. (LBH)

The Association of Academic Health Centers and the Association of American Medical Colleges approved statements on conflicts of interest. University researchers are asked to disclose any significant personal, professional, or financial relationships, and faculty should not let commercially sponsored research interfere with the education of…