The central dogma of molecular biology describes the transfer of genetic information from nucleic acids to proteins and stipulates that the system cannot work in the reverse direction. As a fundamental principle in biology, the dogma is as influential as it is controversial. Some commentators have debated the central dogma's empirical accuracy because they believe that some exceptions are incompatible with the central dogma. We investigated these exceptions challenging the central dogma and conclude that they do not violate the central dogma. The central dogma is still a common model used to describe and study the relationship between genes and proteins. This is one of the greatest established achievements in modern biology.