Reviews the pros and cons of using animals or alternatives in scientific research. Such alternatives (as indicated in congressional bill HR 556) include mathematical models, isolated organs, tissue and cell cultures, computer simulations, mechanical models, and "lower" organisms among others. (SK)

The National Academy of Sciences suggests models for biomedical research which include a biology-wide information system with computerized database accessible from a multitude of dimensions. Links could help discover whether toxic chemicals have effects similar to hormones. Commonalities from molecules to ecosystems might restructure available…