Constructive changes in the practice of investigative interviewing have emerged as a direct result of an unprecedented and robust collaboration between behavioral science researchers and professionals in the field. At the same time, an ever-increasing number of experienced practitioners have shown a willingness to adopt science-based methods in the course of their work. This has highlighted the unique role science plays in this context. Empirical research has been integral to the process of weeding out the pseudoscience that continues to shape training in many corners, while the feedback practitioners can offer scientists as strategies are examined in field conditions helps to refine and focus the research as it moves from basic to applied. Not to be overlooked, science has also been irreplaceable in both the critical examination of past practices (especially as it involves high performers) and in charting the path toward future practices that can supplement and even replace current methodologies.