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Peters, Jamie; Kalivas, Peter W.; Quirk, Gregory J. – Learning & Memory, 2009
Extinction is a form of inhibitory learning that suppresses a previously conditioned response. Both fear and drug seeking are conditioned responses that can lead to maladaptive behavior when expressed inappropriately, manifesting as anxiety disorders and addiction, respectively. Recent evidence indicates that the medial prefrontal cortex (mPFC) is…
Descriptors: Neurological Organization, Brain Hemisphere Functions, Fear, Anxiety