In signaled active avoidance (SigAA), rats learn to suppress Pavlovian freezing and emit actions to remove threats and prevent footshocks. SigAA is critical for understanding aversively motivated instrumental behavior and anxiety-related active coping. However, with standard protocols ~25% of rats exhibit high freezing and poor avoidance. This has…

Traumatic experiences early in life can contribute to the development of mood and anxiety disorders that manifest during adolescence and young adulthood. In young rats exposed to acute fear or stress, alterations in neural development can lead to enduring behavioral abnormalities. Here, we used a modified extinction intervention…

Four articles examining methodological applications of exposure therapy and its limited dissemination were briefly reviewed. Methodological articles included those by Abramowitz et al., Gryczkowski et al., and Weiner and McKay, which addressed couple treatment of obsessive-compulsive disorder (OCD), modification of evidence-based anxiety…

We previously demonstrated that disrupting reconsolidation by pharmacological manipulations "deleted" the emotional expression of a fear memory in humans. If we are to target reconsolidation in patients with anxiety disorders, the disruption of reconsolidation should produce content-limited modifications. At the same time, the fear-erasing effects…

A prior experience of behavioral control over a stressor interferes with subsequent Pavlovian fear conditioning, and this effect is dependent on the activation of the ventral medial prefrontal cortex (mPFCv) at the time of the initial experience with control. It is unknown whether mPFCv activity is necessary during fear learning and/or testing for…

Histone modifications contribute to the epigenetic regulation of gene expression, a process now recognized to be important for the consolidation of long-term memory. Valproic acid (VPA), used for many years as an anticonvulsant and a mood stabilizer, has effects on learning and memory and enhances the extinction of conditioned fear through its…

Extinction of conditioned fear is an important model both of inhibitory learning and of behavior therapy for human anxiety disorders. Like other forms of learning, extinction learning is long-lasting and depends on regulated gene expression. Epigenetic mechanisms make an important contribution to persistent changes in gene expression; therefore,…

Two treatments were compared for reducing anxiety and raising achievement. Significant anxiety reduction occurred in the behavioral group, although following treatment no improvement in achievement occurred. Some implications are discussed. (Author)

FIFTY-FOUR TEST-ANXIOUS COLLEGE FRESHMEN FROM STANFORD UNIVERSITY WERE RANDOMLY ASSIGNED TO ONE OF THREE GROUPS--(1) A DESENSITIZATION GROUP WORKING WITH INDIVIDUALIZED ANXIETY HIERARCHIES, (2) A DESENSITIZATION GROUP WORKING WITH A SINGLE STANDARD HIERARCHY, AND (3) A NO-TREATMENT CONTROL GROUP. THE CRITERIA CONSISTED OF SELF-RATINGS OF ANXIETY…

The author describes a counseling technique which: (1) is based upon behavior theory and treats acts and thoughts as operants, and anxiety as a respondent controlled by classical conditioning; (2) entails in vivo desensitization, requiring the construction of a hierarchy of anxiety-producing situations which can be enacted; (3) uses peer- or…

The purpose of this research was to demonstrate that an audiotape desensitization treatment procedure, administered over a 19-day period, would be an effective means of treating test-taking anxiety. Subjects were students seeking treatment from a university counseling center. Results indicated that the treated subjects showed significant…

Extinction of conditioned fear in animals is the explicit model of behavior therapy for human anxiety disorders, including panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. Based on previous data indicating that fear extinction in rats is blocked by quinpirole, an agonist of dopamine D2 receptors, we hypothesized…

Introduces introductory psychology students to behavioral techniques for reducing anxiety and avoidance behavior through the use of participant modeling. Employs guided participation as a technique to encourage students to touch a snake. Finds this method provides an excellent introduction to behavior therapies and engages students in the learning…