Autism is a complex, behaviorally defined, developmental brain disorder with an estimated prevalence of 1 in 1,000. It is now clear that autism is not a disease, but a syndrome with a strong genetic component. The etiology of autism is poorly defined both at the cellular and the molecular levels. Based on the fact that seizure activity is…

The treatment of seizure disorders and EEG epileptiform abnormalities without epilepsy in children with autism spectrum disorders in considered within the context of the relationship epilepsy and epileptiform disorders to language, behavior, and cognition. The use of anticonvulsants to treat epileptiform discharges thought to be producing…

The efficacy of antiepileptic drugs (AEDs) and psychotropic medications in children with autism is limited to the treatment of seizures or to specific behaviors such as irritability, impulsivity, hyperactivity, repetitive behaviors, or aggression. The reliability and value of the available data--to determine the efficacy of these medications in…

Epileptic encephalopathies are progressive clinical and electroencephalographic syndromes where deterioration is thought to be caused by frequent seizures and abundant EEG epileptiform activity. Seizures occur in approximately 10-15% of children with pervasive developmental disorders (PDD) and 8-10% have epileptiform EEG abnormalities without…

Partially written by a British student with Asperger syndrome, this article recounts the student's experiences of being excluded from a mainstream school due to the school's inability to respond adequately to recurring epileptic seizures. The article suggests that inclusive schools must change to meet students' individual needs and encourage…

Tuberous sclerosis is a genetic condition that is strongly associated with the development of an autism spectrum disorder. However, there is marked variability in expression, and only a subset of children with tuberous sclerosis develop autism spectrum disorder. Clarification of the mechanisms that underlie the association and variability in…

Intended for use in Florida training programs for caregivers of infants and toddlers with disabilities, this booklet describes some of the more common physical and health impairments that can affect young children. For each disability, the description generally stresses typical characteristics and special requirements. Addresses and telephone…

The handbook on Adventures in Movement for the Handicapped (AIM) gives information about general organizational goals and suggests activities for use by volunteer teachers with blind, deaf, crippled, cerebral palsied, mentally retarded, and autistic children at five ability/age levels. General Information given about each handicap usually includes…

Environmental restriction or deprivation early in development can induce social, cognitive, affective, and motor abnormalities similar to those associated with autism. Conversely, rearing animals in larger, more complex environments results in enhanced brain structure and function, including increased brain weight, dendritic branching,…

The Landau-Kleffner syndrome (LKS) and electrical status epilepticus in slow wave sleep (ESES) are rare childhood-onset epileptic encephalopathies in which loss of language skills occurs in the context of an epileptiform EEG activated in sleep. Although in LKS the loss of function is limited to language, in ESES there is a wider spectrum of…

"Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

This booklet provides an overview of autism and discusses strategies for living and working with children with autism. The first section of the guide, "Understanding the Problem," addresses the characteristics of autism, including social symptoms, language difficulties, repetitive behaviors and obsessions, sensory symptoms, and unusual…

Four keynote speeches and 14 sectional presentations comprise the proceedings of the April 1981 Montana Symposium on Early Education and the Exceptional Child. The first speech, entitled "The Yellow Brick Road--Does it Lead to Oz or Abyss?" by B. Fredericks, stresses the importance of gathering solid research evidence to demonstrate that early…

The importance of genetic factors in autism has prompted the development of mutant mouse models to advance our understanding of biological mechanisms underlying autistic behaviors. Mouse models of human neuropsychiatric diseases are designed to optimize (1) face validity, i.e., resemblance to the human symptoms; (2) construct validity, i.e.,…

The shaping of positive attitudes toward the inclusion of children with disabilities is an important aspect of the education of university students preparing to become teachers in regular education. This study examined: (1) components of university student attitudes toward inclusion requests; (2) whether attitudes toward inclusion varied by…