The Early Social Interaction (ESI) Project (Woods & Wetherby, 2003) was designed to apply the recommendations of the National Research Council (2001) to toddlers with autism spectrum disorders (ASD) by using a parent-implemented intervention that (a) embeds naturalistic teaching strategies in everyday routines and (b) is compatible with the…

Screening measures to identify very young children at risk for autism spectrum disorders include the Modified Checklist for Autism in Toddlers (M-CHAT) and the Social Communication Questionnaire (SCQ). To examine the validity of these written questionnaires, parents completed them prior to their child's diagnostic assessment at a tertiary autism…

This article reviews studies linking autistic disorder with various immune factors. It concludes that although various immune system abnormalities have been reported in children with autism, previous studies are largely association based and it remains difficult to draw conclusions regarding the role of immune factors in the etiopathogenesis of…

The Modified Checklist for Autism in Toddlers (M-CHAT), consisting of 23 yes/no items, was used to screen 1,293 children. Of the 58 given a diagnostic/developmental evaluation, 39 were diagnosed with autism. Six items pertaining to social relatedness and communication provided the best means of discrimination among children. (Contains references.)…

This article reviews the developmental profile of a child with autism during the first 3 years of life. Analysis of home videos showed how the child appeared to make progress up to 12 months followed by decreases in social interaction, communication, and language. Discussion suggests that this particular profile is one of the possible pathways…

Thirty-five children diagnosed with autism or pervasive developmental disorders at age 2 were re-evaluated 2 years later for factors related to spoken language development including child variables and environmental variables. After controlling for age 2 language skills, the only significant predictors of age 4 language skills were motor imitation…

This article first reviews early social and communication indicators of autism spectrum disorder (ASD) in infants and toddlers. It then reviews evidence-based intervention practices for children with ASD and identifies principles for providing intervention for infants and toddlers at risk for ASD. Issues addressed include providing intervention in…

This case study of a toddler with autism whose parents had videotaped her development from birth showed that the child's behavior and development were essentially normal for the first year but that she then became withdrawn in only a few months. It is suggested that early communicative screening tests might have identified the child's earliest…

Recent studies have attempted to understand the processes involved in joint attention because of its relevance to both atypical and normal development. Data from a recent study of young children with autism suggests that performance on a delay nonmatch to sample (DNMS) task associated with ventromedial prefrontal functions, but not an…

A study used the Vineland Adaptive Behavior Scales to investigate patterns of adaptive behavior in 30 children with autism who were under 3 years. Relative to controls, participants demonstrated weaker socialization and communication skills and greater discrepancies between adaptive behavior and mental age. The utility of the scales is discussed.…

This article suggests the need to embed social skills intervention within the more general context of long-term early intervention efforts that promote all dimensions of developmental performance. Results from former clients of the LEAP program are discussed and demonstrate evidence of sustained growth and development over nearly two decades.…

Examined the use of protoimperative and protodeclarative pointing gestures in three children with autism (ages 26 to 53 months) at 5-month intervals over two years. Imperative or instrumental functions emerged early in all three; declarative or experience sharing functions emerged later in two subjects and not at all in the third. (DB)

Compared performance of infants with autism, developmental delays, or normal development on a prospective screening instrument for autism. Found that 20-month-olds with autism lacked social gaze in empathy and joint attention tasks. Infants with autism or developmental delays demonstrated functional play. Few produced spontaneous pretend play.…

A study examined the relationship between neuroimaging findings and the behavioral characteristics of 29 patients with tuberous sclerosis. Findings indicate a positive linear relationship between a patient's total number of tubers and degree of intellectual impairment. The number of tubers in the cerebellum was associated with more autistic…

This article comments on results of a study (EC 629 869) on the reliability of the Modified Checklist for Autism in Toddlers (M-CHAT), a early detection screening test. It discusses concerns relating to clinic vs. population samples, data analysis, use of a parent questionnaire only to identify autism, and the age of screening. (Contains…