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Direct linkGiannotti, Flavia; Cortesi, Flavia; Cerquiglini, Antonella; Miraglia, Daniela; Vagnoni, Cristina; Sebastiani, Teresa; Bernabei, Paola – Journal of Autism and Developmental Disorders, 2008
This study investigated sleep of children with autism and developmental regression and the possible relationship with epilepsy and epileptiform abnormalities. Participants were 104 children with autism (70 non-regressed, 34 regressed) and 162 typically developing children (TD). Results suggested that the regressed group had higher incidence of…
Descriptors: Epilepsy, Autism, Sleep, Developmental Disabilities
Scheffer, Ingrid E.; Turner, Samantha J.; Dibbens, Leanne M.; Bayly, Marta A.; Friend, Kathryn; Hodgson, Bree; Burrows, Linda; Shaw, Marie; Wei, Chen; Ullmann, Reinhard; Ropers, Hans-Hilger; Szepetowski, Pierre; Haan, Eric; Mazarib, Aziz; Afawi, Zaid; Neufeld, Miriam Y.; Andrews, P. Ian; Wallace, Geoffrey; Kivity, Sara; Lev, Dorit; Lerman-Sagie, Tally; Derry, Christopher P.; Korczyn, Amos D.; Gecz, Jozef; Mulley, John C.; Berkovic, Samuel F. – Brain, 2008
Epilepsy and Mental Retardation limited to Females (EFMR) which links to Xq22 has been reported in only one family. We aimed to determine if there was a distinctive phenotype that would enhance recognition of this disorder. We ascertained four unrelated families (two Australian, two Israeli) where seizures in females were transmitted through…
Descriptors: Epilepsy, Mental Retardation, Females, Genetics
Molloy, C. A.; Murray, D. S.; Kinsman, A.; Castillo, H.; Mitchell, T.; Hickey, F. J.; Patterson, B. – Journal of Intellectual Disability Research, 2009
Background: Autism occurs 10 times more often in children with Down syndrome than in the general population, but diagnosing co-occurring autism in Down syndrome with severe intellectual disability is challenging. The objective of this case-control study was to identify characteristics differentiating children with trisomy 21 with and without…
Descriptors: Mental Retardation, Autism, Seizures, Down Syndrome
Akshoomoff, Natacha; Farid, Nikdokht; Courchesne, Eric; Haas, Richard – Journal of Autism and Developmental Disorders, 2007
This study examined the nature and frequency of neurological and EEG abnormalities in 60 young children (ages 2-6 years) with pervasive developmental disorders. A number of standard neurological functions could not be adequately assessed due to the young age of the children and/or limited comprehension and cooperation. The most common neurological…
Descriptors: Young Children, Age, Seizures, Autism
Goldstein, Sam, Ed.; Reynolds, Cecil R., Ed. – Guilford Press, 2010
Recognized as the definitive reference in the field, this book addresses a broad range of biologically based disorders that affect children's learning and development. Leading authorities review the genetics of each disorder; its course and outcome; associated developmental, cognitive, and psychosocial challenges; and what clinicians and educators…
Descriptors: Neurological Impairments, Learning Problems, Behavior Problems, Genetics
Moretti, Paolo; Peters, Sarika U.; del Gaudio, Daniela; Sahoo, Trilochan; Hyland, Keith; Bottiglieri, Teodoro; Hopkin, Robert J.; Peach, Elizabeth; Min, Sang Hee; Goldman, David; Roa, Benjamin; Bacino, Carlos A.; Scaglia, Fernando – Journal of Autism and Developmental Disorders, 2008
We studied seven children with CNS folate deficiency (CFD). All cases exhibited psychomotor retardation, regression, cognitive delay, and dyskinesia; six had seizures; four demonstrated neurological abnormalities in the neonatal period. Two subjects had profound neurological abnormalities that precluded formal behavioral testing. Five subjects…
Descriptors: Mental Retardation, Autism, Seizures, Language Skills
Merhar, S. L.; Manning-Courtney, P. – Journal of Autism and Developmental Disorders, 2007
Two children with autism and Klinefelter syndrome (KS) (47, XXY) are presented. Both qualify for the diagnosis of autism based on DSM-IV with severely delayed and disordered language, difficulties with social interaction, and a restricted range of interests and activities. Both also have abnormal EEGs, and one patient has had what appear to be…
Descriptors: Interpersonal Relationship, Measures (Individuals), Pervasive Developmental Disorders, Seizures
Ishijima, Michiko; Kurita, Hiroshi – Journal of Autism and Developmental Disorders, 2007
The first case study of identical male twins concordant for DSM-IV Asperger's disorder (ASD) was presented. Their monozygocity was confirmed by short tandem repeat analyses with a probability of 99.999963%. Despite sharing the same DNA and environment, the twins are different in comorbidity (i.e., major depressive disorder in the elder and absence…
Descriptors: Case Studies, Behavior Problems, Probability, Neurology
Selassie, G. Rejno-Habte; Viggedal, G.; Olsson, I.; Jennische, M. – Developmental Medicine & Child Neurology, 2008
We studied expressive and receptive language, oral motor ability, attention, memory, and intelligence in 20 6-year-old children with epilepsy (14 females, six males; mean age 6y 5mo, range 6y-6y 11mo) without learning disability, cerebral palsy (CP), and/or autism, and in 30 reference children without epilepsy (18 females, 12 males; mean age 6y…
Descriptors: Epilepsy, Autism, Learning Disabilities, Seizures
Peer reviewedSmalley, Susan L.; And Others – Journal of Autism and Developmental Disorders, 1992
A literature review of autism and tuberous sclerosis complex (TSC) substantiates a significant association between the two. Studies of 14 autistic probands and 13 TSC probands identified 7 TSC subjects with autism, who had more seizures and mental retardation than those without autism. More male TSC probands with autism than female were…
Descriptors: Autism, Correlation, Genetics, Heredity
Walz, Nicolay Chertkoff – Journal of Autism and Developmental Disorders, 2007
Research examining autistic symptoms in Angelman syndrome (AS) is limited. The goal of this study was to further characterize the nature of stereotyped behaviors, social interaction deficits, and developmental disturbances in individuals with AS. Parents of 248 individuals between the ages of 3 and 22 completed a survey of autistic symptomatology…
Descriptors: Language Skills, Interpersonal Relationship, Rating Scales, Expressive Language
Peer reviewedTaft, Lawrence T.; Cohen, Herbert J. – Journal of Autism and Childhood Schizophrenia, 1971
Descriptors: Autism, Case Studies, Drug Therapy, Emotional Disturbances
Malow, Beth A. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
The purpose of this review article is to describe the clinical data linking autism with sleep and epilepsy and to discuss the impact of treating sleep disorders in children with autism either with or without coexisting epileptic seizures. Studies are presented to support the view that sleep is abnormal in individuals with autistic spectrum…
Descriptors: Epilepsy, Autism, Seizures, Sleep
Peer reviewedWilliamson, David A.; Bolton, Patrick – Journal of Autism and Developmental Disorders, 1995
This report describes a sibling pair (ages 21 and 18), both with tuberous sclerosis. One sibling has atypical autism (but no mental retardation or seizure disorder) and the other has a seizure disorder but no autism or mental retardation. Both siblings had multiple bilateral brain lesions. Clinical findings are discussed in relationship to the…
Descriptors: Autism, Clinical Diagnosis, Medical Evaluation, Mental Retardation
Peer reviewedKanner, Andres M. – Journal of Autism and Developmental Disorders, 2000
This commentary reviews studies of children with Landau-Kleffner Syndrome (LKS) and autistic regression (AR) and concludes that they are two distinct entities with different epileptic profiles and that the treatment modalities used in LKS cannot be expected to yield a therapeutic effect in AR. Multiple Subpial Transection is discussed. (Contains…
Descriptors: Autism, Children, Epilepsy, Individual Characteristics
