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Direct linkLewis, Mark H. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
Environmental restriction or deprivation early in development can induce social, cognitive, affective, and motor abnormalities similar to those associated with autism. Conversely, rearing animals in larger, more complex environments results in enhanced brain structure and function, including increased brain weight, dendritic branching,…
Descriptors: Autism, Seizures, Brain, Neurology
Crawley, Jacqueline N. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
The importance of genetic factors in autism has prompted the development of mutant mouse models to advance our understanding of biological mechanisms underlying autistic behaviors. Mouse models of human neuropsychiatric diseases are designed to optimize (1) face validity, i.e., resemblance to the human symptoms; (2) construct validity, i.e.,…
Descriptors: Genetic Disorders, Animals, Autism, Seizures
