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Prenatal Programming of Developmental Trajectories for Obesity Risk and Early Pubertal Timing
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Robertson, Olivia C.; Marceau, Kristine; Duncan, Robert J.; Shirtcliff, Elizabeth A.; Leve, Leslie D.; Shaw, Daniel S.; Natsuaki, Misaki; Neiderhiser, Jenae M.; Ganiban, Jody M. – Developmental Psychology, 2022
The thrifty phenotype and fetal overnutrition hypotheses are two developmental hypotheses that originated from the "developmental origins of health and disease" (DOHaD) perspective. The DOHaD posits that exposures experienced prenatally and early in life may influence health outcomes through altering form and function of internal organs…
Descriptors: Obesity, At Risk Persons, Child Development, Puberty
Parenting and Prenatal Risk as Moderators of Genetic Influences on Conduct Problems during Middle Childhood
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Marceau, Kristine; Rolan, Emily; Leve, Leslie D.; Ganiban, Jody M.; Reiss, David; Shaw, Daniel S.; Natsuaki, Misaki N.; Egger, Helen L.; Neiderhiser, Jenae M. – Developmental Psychology, 2019
This study examines interactions of heritable influences, prenatal substance use, and postnatal parental warmth and hostility on the development of conduct problems in middle childhood for boys and girls. Participants are 561 linked families, collected in 2 cohorts, including birth parents, adoptive parents, and adopted children. Heritable…
Descriptors: Genetics, Substance Abuse, Prenatal Influences, Perinatal Influences
Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
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Zerbo, Ousseny; Iosif, Ana-Maria; Walker, Cheryl; Ozonoff, Sally; Hansen, Robin L.; Hertz-Picciotto, Irva – Journal of Autism and Developmental Disorders, 2013
We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though…
Descriptors: Pregnancy, Developmental Delays, Genetics, Autism
The Generation R Study: A Review of Design, Findings to Date, and a Study of the 5-HTTLPR by Environmental Interaction from Fetal Life Onward
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Tiemeier, Henning; Velders, Fleur P.; Szekely, Eszter; Roza, Sabine J.; Dieleman, Gwen; Jaddoe, Vincent W. V.; Uitterlinden, Andre G.; White, Tonya J. H.; Bakermans-Kranenburg, Marian J.; Hofman, Albert; Van IJzendoorn, Marinus H.; Hudziak, James J.; Verhulst, Frank C. – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: First, we give an overview of child psychiatric research in the Generation R Study, a population-based cohort from fetal life forward. Second, we examine within Generation R whether the functional polymorphism (5-HTTLPR) in the promoter of the serotonin transporter gene interacts with prenatal maternal chronic difficulties, prenatal…
Descriptors: Pregnancy, Emotional Development, Anxiety, Emotional Problems
The Prodrome of Autism: Early Behavioral and Biological Signs, Regression, Peri- and Post-Natal Development and Genetics
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Yirmiya, Nurit; Charman, Tony – Journal of Child Psychology and Psychiatry, 2010
Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the "core" disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical…
Descriptors: Symptoms (Individual Disorders), Autism, Infants, Genetics
Prenatal and Early Life Risk Factors of Schizophrenia
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Lattari, Fallon; Dragowski, Eliza A. – Communique, 2011
Childhood-onset schizophrenia is an exceedingly rare mental illness whose complex, multifaceted behavioral presentation can disrupt child development and raise diagnostic and treatment difficulties for attending clinicians. The disorder, affecting one in 30,000 children, shares the same diagnostic criteria and symptoms as its adult counterpart,…
Descriptors: Schizophrenia, Symptoms (Individual Disorders), Child Development, At Risk Persons
Pre- and Peri-Natal Environmental Risks for Attention-Deficit Hyperactivity Disorder (ADHD): The Potential Role of Epigenetic Processes in Mediating Susceptibility
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Mill, Jonathan; Petronis, Arturas – Journal of Child Psychology and Psychiatry, 2008
Attention-deficit hyperactivity disorder (ADHD) is a common childhood neurobehavioural disorder defined by symptoms of developmentally inappropriate inattention, impulsivity and hyperactivity. As is the norm for most psychiatric phenotypes, traditional aetiological studies have focused primarily on the interplay between genetic and environmental…
Descriptors: Attention Deficit Hyperactivity Disorder, Child Behavior, Behavior Problems, Environmental Influences
The Dopamine Receptor D4 7-Repeat Allele and Prenatal Smoking in ADHD-Affected Children and Their Unaffected Siblings: No Gene-Environment Interaction
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Altink, Marieke E.; Arias-Vasquez, Alejandro; Franke, Barbara; Slaats-Willemse, Dorine I. E.; Buschgens, Cathelijne J. M.; Rommelse, Nanda N. J.; Fliers, Ellen A.; Anney, Richard; Brookes, Keeley-Joanne; Chen, Wai; Gill, Michael; Mulligan, Aisling; Sonuga-Barke, Edmund; Thompson, Margaret; Sergeant, Joseph A.; Faraone, Stephen V.; Asherson, Philip; Buitelaar, Jan K. – Journal of Child Psychology and Psychiatry, 2008
Background: The dopamine receptor D4 ("DRD4") 7-repeat allele and maternal smoking during pregnancy are both considered as risk factors in the aetiology of attention deficit hyperactivity disorder (ADHD), but few studies have been conducted on their interactive effects in causing ADHD. The purpose of this study is to examine the gene by…
Descriptors: Siblings, Smoking, Attention Deficit Hyperactivity Disorder, Pregnancy
Assessment of Gestational Age and Neuromaturation
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Allen, Marilee C. – Mental Retardation and Developmental Disabilities Research Reviews, 2005
Neuromaturation is the functional development of the central nervous system (CNS). It is by its very nature a dynamic process, a continuous interaction between the genome and first the intrauterine environment, then the extrauterine environment. Understanding neuromaturation and being able to measure it is fundamental to infant neurodevelopmental…
Descriptors: Early Intervention, Pregnancy, Infants, Anatomy
Necessary but Not Sufficient: The Respective Roles of Single and Multiple Influences on Individual Development.
Wachs, Theodore D. – 2000
Based on the view that individual variability is best understood as the result of influences from multiple domains operating over time, this book describes how different domains of influence operate, describes the operating processes in common to the different influences, and shows how these processes meet the criteria for a full-fledged system.…
Descriptors: At Risk Persons, Biological Influences, Child Development, Cultural Influences