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The Generation R Study: A Review of Design, Findings to Date, and a Study of the 5-HTTLPR by Environmental Interaction from Fetal Life Onward
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Tiemeier, Henning; Velders, Fleur P.; Szekely, Eszter; Roza, Sabine J.; Dieleman, Gwen; Jaddoe, Vincent W. V.; Uitterlinden, Andre G.; White, Tonya J. H.; Bakermans-Kranenburg, Marian J.; Hofman, Albert; Van IJzendoorn, Marinus H.; Hudziak, James J.; Verhulst, Frank C. – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: First, we give an overview of child psychiatric research in the Generation R Study, a population-based cohort from fetal life forward. Second, we examine within Generation R whether the functional polymorphism (5-HTTLPR) in the promoter of the serotonin transporter gene interacts with prenatal maternal chronic difficulties, prenatal…
Descriptors: Pregnancy, Emotional Development, Anxiety, Emotional Problems
Adult Outcomes of Childhood Dysregulation: A 14-Year Follow-up Study
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Althoff, Robert R.; Verhulst, Frank C.; Rettew, David C.; Hudziak, James J.; van der Ende, Jan – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Using a general population sample, the adult outcomes of children who presented with severe problems with self-regulation defined as being concurrently rated highly on attention problems, aggressive behavior, and anxious-depression on the Child Behavior Checklist-Dysregulation Profile (CBCL-DP) were examined. Method: Two thousand…
Descriptors: Anxiety Disorders, Check Lists, Aggression, Drug Abuse