The Colorado Children's Campaign began 2021 focused on their mission as the pandemic laid bare the many systemic barriers faced by kids and families in Colorado. Despite the economic downturn and unpredictable school schedules, the new year brought with it an urgency to restructure socioeconomic systems to benefit all Coloradans. This 2021 Annual Report summarizes Colorado Children's Campaign's advocacy, research, development, and outreach efforts in 2021. [For the 2020 Annual Report, see ED614212.]